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Q7V2B2 (Q7V2B2_PROMP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003440
EC=3.5.2.3 RuleBase RU003440
Gene names
Name:pyrC EMBL CAE19028.1
Ordered Locus Names:PMM0569
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003440 SAAS SAAS004721

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003440 SAAS SAAS004721

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003440 SAAS SAAS004721

Subunit structure

Homodimer By similarity. SAAS SAAS004721

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. RuleBase RU003440

Sequences

Sequence LengthMass (Da)Tools
Q7V2B2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: CC02F5AAE02EC927

FASTA34939,958
        10         20         30         40         50         60 
MKELTISKPD DWHLHLREGI VLKNIIRFTS QYFGRAIVMP NTKNPITSIE KCISYKNSIF 

        70         80         90        100        110        120 
EALSNNSTFE PLMTIYLTDE TIKHELVEGF KNKVFFAAKL YPANATTNSR HGVKKIENLY 

       130        140        150        160        170        180 
EIFEVMQELG MPLLIHGEVT DPEVDIFDRE EVFIDKELSP LIQQFPRLKI VLEHITTSYA 

       190        200        210        220        230        240 
VDFVQRNNLG ATITPHHLHI NRNAMFFGGL NSDFYCLPVA KRENNRIALR KAATSGKECF 

       250        260        270        280        290        300 
FIGTDSAPHL RQWKAFCGCA GIFNSPVAIE SYLKVFEEEN ALNQFEKFAS LNGPNFYNLP 

       310        320        330        340 
INNEKIRLVS RSNKIPEFIE VIEQNKVVGQ IKPFHGGETL TWRVEGVVK

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References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548174 Genomic DNA. Translation: CAE19028.1.
RefSeqNP_892687.1. NC_005072.1.

3D structure databases

HSSPHSSP built from PDB template 1J79 based on UniProtKB P05020.
ProteinModelPortalQ7V2B2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7V2B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1726624.
GenomeReviewsGene locus PMM0569 in contig BX548174_GR.
KEGGpmm:PMM0569.
NMPDRfig|59919.1.peg.566.
PATRIC23031906. VBIProMar68066_0623.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHBG628648.
OMACLPVAKR.
PhylomeDBQ7V2B2.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycPMAR167540:PMM0569-MONOMER.

Family and domain databases

InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. PyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7V2B2_PROMP
AccessionPrimary (citable) accession number: Q7V2B2
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info