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Q7V286

- SYW_PROMP

UniProt

Q7V286 - SYW_PROMP

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei203 – 2031ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59919:GJMQ-619-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:PMM0598
    OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
    Taxonomic identifieri59919 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001026: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Tryptophan--tRNA ligasePRO_0000136661Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi59919.PMM0598.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi13 – 219"HIGH" region
    Motifi200 – 2045"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059940.
    KOiK01867.
    OMAiRAKSDSY.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V286-1 [UniParc]FASTAAdd to Basket

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    MTNKKRILSG VQPTGDLHIG NWLGAINNWV ELQEKHETFL CVVDLHAITT    50
    EYDTKQLSKN TLSTAALYIA CGINPKICSI FVQSQISAHS ELCWILNCMT 100
    PINWMERMIQ FKEKSIQQGN NVSIGLFDYP ILMAADILLY DADYVPVGED 150
    QKQHLELAKD IAQQRINAKF GKEENILKIP QPIIMKKGSK IMSLNDGSKK 200
    MSKSDINEGS RINLLDTPEI ITKKIKRAKS DSYMGMEFNN PERPESRNLL 250
    MIYSLLSGKE VSELENDLSQ TGWGTFKKIF TEQIIESLKP IQERYQVLIN 300
    DPHELNKILI QGKEKAEVVA NKTLSRVKSE LGFFEIEK 338
    Length:338
    Mass (Da):38,463
    Last modified:October 1, 2003 - v1
    Checksum:i03AE06A283DD2A9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548174 Genomic DNA. Translation: CAE19057.1.
    RefSeqiNP_892716.1. NC_005072.1.

    Genome annotation databases

    EnsemblBacteriaiCAE19057; CAE19057; PMM0598.
    GeneIDi1726704.
    KEGGipmm:PMM0598.
    PATRICi23031968. VBIProMar68066_0653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548174 Genomic DNA. Translation: CAE19057.1 .
    RefSeqi NP_892716.1. NC_005072.1.

    3D structure databases

    ProteinModelPortali Q7V286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59919.PMM0598.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE19057 ; CAE19057 ; PMM0598 .
    GeneIDi 1726704.
    KEGGi pmm:PMM0598.
    PATRICi 23031968. VBIProMar68066_0653.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059940.
    KOi K01867.
    OMAi RAKSDSY.
    OrthoDBi EOG686NJQ.

    Enzyme and pathway databases

    BioCyci PMAR59919:GJMQ-619-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCMP1986 / MED4.

    Entry informationi

    Entry nameiSYW_PROMP
    AccessioniPrimary (citable) accession number: Q7V286
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3