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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136L-tryptophanUniRule annotation1
Binding sitei191ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 14ATPUniRule annotation3
Nucleotide bindingi20 – 21ATPUniRule annotation2
Nucleotide bindingi148 – 150ATPUniRule annotation3
Nucleotide bindingi200 – 204ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59919:G1G3M-637-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:PMM0598
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001026 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366611 – 338Tryptophan--tRNA ligaseAdd BLAST338

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi59919.PMM0598

Structurei

3D structure databases

ProteinModelPortaliQ7V286
SMRiQ7V286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi13 – 21"HIGH" regionUniRule annotation9
Motifi200 – 204"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q7V286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKKRILSG VQPTGDLHIG NWLGAINNWV ELQEKHETFL CVVDLHAITT
60 70 80 90 100
EYDTKQLSKN TLSTAALYIA CGINPKICSI FVQSQISAHS ELCWILNCMT
110 120 130 140 150
PINWMERMIQ FKEKSIQQGN NVSIGLFDYP ILMAADILLY DADYVPVGED
160 170 180 190 200
QKQHLELAKD IAQQRINAKF GKEENILKIP QPIIMKKGSK IMSLNDGSKK
210 220 230 240 250
MSKSDINEGS RINLLDTPEI ITKKIKRAKS DSYMGMEFNN PERPESRNLL
260 270 280 290 300
MIYSLLSGKE VSELENDLSQ TGWGTFKKIF TEQIIESLKP IQERYQVLIN
310 320 330
DPHELNKILI QGKEKAEVVA NKTLSRVKSE LGFFEIEK
Length:338
Mass (Da):38,463
Last modified:October 1, 2003 - v1
Checksum:i03AE06A283DD2A9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA Translation: CAE19057.1
RefSeqiWP_011132232.1, NC_005072.1

Genome annotation databases

EnsemblBacteriaiCAE19057; CAE19057; PMM0598
KEGGipmm:PMM0598

Similar proteinsi

Entry informationi

Entry nameiSYW_PROMP
AccessioniPrimary (citable) accession number: Q7V286
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health