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Q7V209 (AROB_PROMP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:PMM0682
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3633633-dehydroquinate synthase HAMAP MF_00110
PRO_0000140767

Sequences

Sequence LengthMass (Da)Tools
Q7V209 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2EFACAABA16C020A

FASTA36340,622
        10         20         30         40         50         60 
MHKNKILVPL SNNSYEVIIK QGLINNIGEE LIRIGINSNR KILIVSNKEI STLFGRKLLN 

        70         80         90        100        110        120 
NLKKNNFNAE IFNIKAGESH KNFASLSEIF NAAFEVGLDR NSLLIALGGG IVGDVTGFAA 

       130        140        150        160        170        180 
ATWLRGIEYI QIPTTLLSMV DSSVGGKTAV NHPKGKNLIG AFYQPKAVFI DPETLITLPT 

       190        200        210        220        230        240 
REFKAGMAEV IKYGVIKDKS LFEYLENEKN RDKILNLENE SLIKIINKSI KTKACIVSED 

       250        260        270        280        290        300 
EKENGIRAIL NYGHSFGHVI ENLCGYGEYL HGEAISIGMK IAGDIATEKN LWSKEHSLRQ 

       310        320        330        340        350        360 
DHLIESYGLP IQTPKIKKND VMKILMGDKK VRNGKMRFIL PIELGEVDIF NDINESQFLK 


YFN

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548174 Genomic DNA. Translation: CAE19141.1.
RefSeqNP_892800.1. NC_005072.1.

3D structure databases

ProteinModelPortalQ7V209.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7V209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1727029.
GenomeReviewsGene locus PMM0682 in contig BX548174_GR.
KEGGpmm:PMM0682.
NMPDRfig|59919.1.peg.679.
PATRIC23032158. VBIProMar68066_0747.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ7V209.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycPMAR167540:PMM0682-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PROMP
AccessionPrimary (citable) accession number: Q7V209
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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