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Q7V1M1 (ACSF_PROMP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
EC=1.14.13.81
Gene names
Name:acsF
Ordered Locus Names:PMM0844
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840

Catalytic activity

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Cofactor

Iron By similarity. HAMAP MF_01840

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840

Sequence similarities

Belongs to the AcsF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
PRO_0000217532

Sequences

Sequence LengthMass (Da)Tools
Q7V1M1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: A55456142B4B34BF

FASTA39045,980
        10         20         30         40         50         60 
MAQQTIESNN KKSVNRGKDI AKDTILTPNF YTTDFEAMEK MDLSINEDEL EAICEEFRKD 

        70         80         90        100        110        120 
YNRHHFVRNK EFEGAADKID AETRELFVDF LEGSCTSEFS GFLLYKELSK RIKDKNPLLA 

       130        140        150        160        170        180 
ECFAHMARDE ARHAGFLNKS MNDFGLQLDL GFLTANKDYT YFAPRAIFYA TYISEKIGYW 

       190        200        210        220        230        240 
RYIAIYRHLE KNPSGKIFPL FNFFENWCQD ENRHGDFFDA LMKAQPRTVK SLSQKIEIFG 

       250        260        270        280        290        300 
YTLKHPIFDY YHRFRYFLNN HPIVSKLWSR FFLLAVFATM YIRDLGTKRN FYGALGLNAR 

       310        320        330        340        350        360 
EYDQFVINKT NETSAKVFPV VLNVYDKSFY KRLDRIVENG TRLSEIDKKE NPNVIKVLSK 

       370        380        390 
LPIFISNGYQ LIRLYLLKPL ESDDFQPSIR

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548174 Genomic DNA. Translation: CAE19303.1.
RefSeqNP_892962.1. NC_005072.1.

3D structure databases

ProteinModelPortalQ7V1M1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7V1M1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1727176.
GenomeReviewsGene locus PMM0844 in contig BX548174_GR.
KEGGpmm:PMM0844.
NMPDRfig|59919.1.peg.841.
PATRIC23032568. VBIProMar68066_0951.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHBG284843.
OMAHGDFFDA.
PhylomeDBQ7V1M1.
ProtClustDBPRK13654.

Enzyme and pathway databases

BioCycPMAR167540:PMM0844-MONOMER.

Family and domain databases

HAMAPMF_01840. AcsF.
[Tree]
InterProIPR008434. AcsF.
IPR012347. Ferritin-rel.
IPR009078. Ferritin/RR-like.
IPR003251. Rubrerythrin.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KOK04035.
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACSF_PROMP
AccessionPrimary (citable) accession number: Q7V1M1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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