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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-914-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PMM0889
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligasePRO_0000152065Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM0889.

Structurei

3D structure databases

ProteinModelPortaliQ7V1I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V1I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITSENTDNR ATNLYKPSDI EGKWQKIWED DNLYNTDEQA SNKEKFYALS
60 70 80 90 100
MFPYPSGNLH MGHVRNYVIT DLIARFQRFQ GKVVLHPMGW DAFGLPAENA
110 120 130 140 150
AIERGINPDK WTKQNIAHMK SQLKLLGLSV DWDREFATCD ENYYVWTQFL
160 170 180 190 200
FLELHKAGLV YQKESEVNWD PIDNTVLANE QVDSEGKSWR SGAIVEKKLL
210 220 230 240 250
TQWFLKITDY AEELLQDLEK LNEWPERVKI MQENWIGKSI GTNINFKIKE
260 270 280 290 300
FKKEKIQVFT TRPDTLFGVT YLAISVNHPL IKKISDNKIL SKLENLKIYL
310 320 330 340 350
QESKDKDQKK IGIPTNLIAI NPINSKEIPI LIASYVLDEY GTGAVMGVPA
360 370 380 390 400
HDERDFEFAK INSIDIKQVI IKEKDKITSQ LTNAFTDNGF LINSNNFDGL
410 420 430 440 450
NNSDAKKHIS EHGERNGWAE NKIQFRLRDW LISRQRYWGC PIPIIKCTNC
460 470 480 490 500
GSVPVNKKDI PVRLPNEIKI SSNKINSLGS NQSWINTTCP KCGNLASRET
510 520 530 540 550
DTMDTFMCSS WYFLRYPSSK SLTKPFEKEK INKWLPVDQY VGGVEHAILH
560 570 580 590 600
LLYARFLTKA LRDNNLFDID EPFKRLLTQG MVQSAAYKNS ITGKYISPTD
610 620 630 640 650
IKDITNPKDP KDNSKLEVLF EKMSKSKYNG IDPESVIKKY GADTARMFIL
660 670 680 690 700
FKAPPEKDLE WGDSDVEGQY RFLCRIWKLF LDYSNNDITH EADKLKKENE
710 720 730 740 750
SSLLKSINIA IKEISNDIKN NQFNTAISEL MKFYNSISSN LNYVNKDLRR
760 770 780 790 800
ESLMKFCILL APFAPHISDE IWHLIGNSKS VHLEKWPVFD EDALKENSFE
810 820 830 840 850
LVIQINGKVR DKINVEINIS DDEIKEKTLI RPNVKKWIDN KTIRKIIIVK

GRIINIVV
Length:858
Mass (Da):99,148
Last modified:October 1, 2003 - v1
Checksum:i8CE816904876088F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE19348.1.
RefSeqiNP_893007.1. NC_005072.1.
WP_011132522.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE19348; CAE19348; PMM0889.
KEGGipmm:PMM0889.
PATRICi23032694. VBIProMar68066_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE19348.1.
RefSeqiNP_893007.1. NC_005072.1.
WP_011132522.1. NC_005072.1.

3D structure databases

ProteinModelPortaliQ7V1I2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59919.PMM0889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE19348; CAE19348; PMM0889.
KEGGipmm:PMM0889.
PATRICi23032694. VBIProMar68066_1012.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-914-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiSYL_PROMP
AccessioniPrimary (citable) accession number: Q7V1I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.