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Q7V1I2

- SYL_PROMP

UniProt

Q7V1I2 - SYL_PROMP

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Protein
Leucine--tRNA ligase
Gene
leuS, PMM0889
Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-914-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PMM0889
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligaseUniRule annotation
PRO_0000152065Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM0889.

Structurei

3D structure databases

ProteinModelPortaliQ7V1I2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 6311"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V1I2-1 [UniParc]FASTAAdd to Basket

« Hide

MITSENTDNR ATNLYKPSDI EGKWQKIWED DNLYNTDEQA SNKEKFYALS    50
MFPYPSGNLH MGHVRNYVIT DLIARFQRFQ GKVVLHPMGW DAFGLPAENA 100
AIERGINPDK WTKQNIAHMK SQLKLLGLSV DWDREFATCD ENYYVWTQFL 150
FLELHKAGLV YQKESEVNWD PIDNTVLANE QVDSEGKSWR SGAIVEKKLL 200
TQWFLKITDY AEELLQDLEK LNEWPERVKI MQENWIGKSI GTNINFKIKE 250
FKKEKIQVFT TRPDTLFGVT YLAISVNHPL IKKISDNKIL SKLENLKIYL 300
QESKDKDQKK IGIPTNLIAI NPINSKEIPI LIASYVLDEY GTGAVMGVPA 350
HDERDFEFAK INSIDIKQVI IKEKDKITSQ LTNAFTDNGF LINSNNFDGL 400
NNSDAKKHIS EHGERNGWAE NKIQFRLRDW LISRQRYWGC PIPIIKCTNC 450
GSVPVNKKDI PVRLPNEIKI SSNKINSLGS NQSWINTTCP KCGNLASRET 500
DTMDTFMCSS WYFLRYPSSK SLTKPFEKEK INKWLPVDQY VGGVEHAILH 550
LLYARFLTKA LRDNNLFDID EPFKRLLTQG MVQSAAYKNS ITGKYISPTD 600
IKDITNPKDP KDNSKLEVLF EKMSKSKYNG IDPESVIKKY GADTARMFIL 650
FKAPPEKDLE WGDSDVEGQY RFLCRIWKLF LDYSNNDITH EADKLKKENE 700
SSLLKSINIA IKEISNDIKN NQFNTAISEL MKFYNSISSN LNYVNKDLRR 750
ESLMKFCILL APFAPHISDE IWHLIGNSKS VHLEKWPVFD EDALKENSFE 800
LVIQINGKVR DKINVEINIS DDEIKEKTLI RPNVKKWIDN KTIRKIIIVK 850
GRIINIVV 858
Length:858
Mass (Da):99,148
Last modified:October 1, 2003 - v1
Checksum:i8CE816904876088F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE19348.1.
RefSeqiNP_893007.1. NC_005072.1.
WP_011132522.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE19348; CAE19348; PMM0889.
GeneIDi1726569.
KEGGipmm:PMM0889.
PATRICi23032694. VBIProMar68066_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE19348.1 .
RefSeqi NP_893007.1. NC_005072.1.
WP_011132522.1. NC_005072.1.

3D structure databases

ProteinModelPortali Q7V1I2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59919.PMM0889.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE19348 ; CAE19348 ; PMM0889 .
GeneIDi 1726569.
KEGGi pmm:PMM0889.
PATRICi 23032694. VBIProMar68066_1012.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR59919:GJMQ-914-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiSYL_PROMP
AccessioniPrimary (citable) accession number: Q7V1I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi