Q7V1I1 (G6PI_PROMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	PMM0890

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]

Taxonomic identifier

59919 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180706
Sites
	Active site	323	1	Proton donor By similarity
	Active site	352	1	By similarity
	Active site	454	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7V1I1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: A785CE626C2AD6CA	FASTA	526	59,307
	10 20 30 40 50 60 MNNDFNSWDK YCNYLWFDKQ VNIWLDISKI NFTLDQISSL ENKFKKVFSA LKELEAGAIS 70 80 90 100 110 120 NIDEKRQVGH YWLRNPSVAP SNLIKDAINN EIRDISEFGE KILEGKITNN KNQKFTNVLW 130 140 150 160 170 180 IGIGGSGLGP LLITEALQEN SCGLNFSYID NIDPFLISEK LDELSDKLAT TLFVVVSKSG 190 200 210 220 230 240 GTPEPKIAMN IIKKHVENKN LDWNSNAIAI TMKDSQLYKK AQLENWLKIF NLPDWVGGRT 250 260 270 280 290 300 SITSSVGLLP LALINRDVSE FIKGAAIMDD LTRIPNIKDN PAALLSSAWF FSGDGIGKRD 310 320 330 340 350 360 MVVLPYRDRL QVFSKYLQQL VMESLGKKFN RKGEIVHQGI SVFGNKGSTD QHAYVQQLRD 370 380 390 400 410 420 GIDNFFCVFI ELLDTPNSNF YFDSENPKEF LSGFLQGTRS ALSNENRQSI TITLDKLSCL 430 440 450 460 470 480 TLGALIALFE RAVSFYAELV DINAYDQPGV EAGKKAAAEI IDYQKQVTEI FNNGEELSIK 490 500 510 520 EITSLLRNSS AEPIFFIIRQ MCFGNDDYLI NGDWSKPSTI RIKKIS

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CCMP1986 / MED4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX548174 Genomic DNA. Translation: CAE19349.1.
RefSeq	NP_893008.1. NC_005072.1.
3D structure databases
ProteinModelPortal	Q7V1I1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7V1I1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1726594.
GenomeReviews	Gene locus PMM0890 in contig BX548174_GR.
KEGG	pmm:PMM0890.
NMPDR	fig|59919.1.peg.887.
PATRIC	23032696. VBIProMar68066_1013.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG285902.
OMA	RTSITSA.
PhylomeDB	Q7V1I1.
ProtClustDB	PRK14096.
Enzyme and pathway databases
BioCyc	PMAR167540:PMM0890-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_PROMP

Accession

Primary (citable) accession number: Q7V1I1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program