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Q7V1H9 (ARGC_PROMP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase
Gene names
Name:argC
Ordered Locus Names:PMM0892
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150

Subcellular location

Cytoplasm Probable HAMAP MF_00150.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: EC

NAD binding

Inferred from electronic annotation. Source: InterPro

protein dimerization activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
PRO_0000112436

Sites

Active site1541 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7V1H9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 95346DD20D647136

FASTA35138,781
        10         20         30         40         50         60 
MNVAIVGATG YGGIQAVNLL KSNKNYKISY LGGNKSSGTK WSDNFPFINL ESDNLIEKIS 

        70         80         90        100        110        120 
IDRIADKANV ALLCLPNGIS STLTRGLLEK GVKVIDLSAD YRYKSLDQWK NIYSNEAKKY 

       130        140        150        160        170        180 
KRDDDDLCKE AVYGLPEINF NDISKARLIA SPGCYPTSAL IPLNPFLSQG IIDNEGIVID 

       190        200        210        220        230        240 
SKSGTSGGGR EPNQKSLFSE CGDGLSAYGL INHRHTSEIE QIASFISGND IELLFTPHLI 

       250        260        270        280        290        300 
PMTRGMHSTI YGRLRDPGLT SSDCRIILEN YYRNYSHIRV LPVDIYPSTK WVKNTNEIHL 

       310        320        330        340        350 
SVKVDTRNGR VIILSVIDNL IKGQTGQAIQ NLNLISGLPI NNGLEMINHY P

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548174 Genomic DNA. Translation: CAE19351.1.
RefSeqNP_893010.1. NC_005072.1.

3D structure databases

ProteinModelPortalQ7V1H9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7V1H9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1726574.
GenomeReviewsGene locus PMM0892 in contig BX548174_GR.
KEGGpmm:PMM0892.
NMPDRfig|59919.1.peg.889.
PATRIC23032700. VBIProMar68066_1015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0002.
HOGENOMHBG294213.
OMATAEDCTT.
PhylomeDBQ7V1H9.
ProtClustDBPRK00436.

Enzyme and pathway databases

BioCycPMAR167540:PMM0892-MONOMER.

Family and domain databases

HAMAPMF_00150. ArgC_type1.
[Tree]
InterProIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00145.
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01850. ArgC. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC_PROMP
AccessionPrimary (citable) accession number: Q7V1H9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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