ID   PPNK2_PROMP             Reviewed;         302 AA.
AC   Q7V0I8;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Probable inorganic polyphosphate/ATP-NAD kinase 2;
DE            Short=Poly(P)/ATP NAD kinase 2;
DE            EC=2.7.1.23;
GN   Name=ppnK2; OrderedLocusNames=PMM1269;
OS   Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4).
OC   Bacteria; Cyanobacteria; Prochlorophytes; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22825698; PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P.,
RA   Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R.,
RA   Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M.,
RA   Shaw S.L., Steglich C., Sullivan M.B., Ting C.S., Tolonen A.,
RA   Webb E.A., Zinser E.R., Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic
RT   niche differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Catalyzes the phosphorylation of NAD to NADP. Utilizes
CC       ATP and other nucleoside triphosphates as well as inorganic
CC       polyphosphate as a source of phosphorus (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + NAD(+) = ADP + NADP(+).
CC   -!- COFACTOR: Divalent metal ions (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD kinase family.
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DR   EMBL; BX548174; CAE19728.1; -; Genomic_DNA.
DR   RefSeq; NP_893386.1; -.
DR   GeneID; 1726270; -.
DR   GenomeReviews; BX548174_GR; PMM1269.
DR   KEGG; pmm:PMM1269; -.
DR   NMPDR; fig|59919.1.peg.1265; -.
DR   HOGENOM; Q7V0I8; -.
DR   OMA; Q7V0I8; NDGKELA.
DR   BioCyc; PMAR167540:PMM1269-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:HAMAP.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:HAMAP.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   HAMAP; MF_00361; -; 1.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_all-b.
DR   InterPro; IPR002504; ATP_NADK.
DR   Gene3D; G3DSA:2.60.200.30; ATP-NAD_kinase_PpnK-typ; 1.
DR   PANTHER; PTHR20275; ATP_NADK; 1.
DR   Pfam; PF01513; NAD_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; NAD; NADP;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    302       Probable inorganic polyphosphate/ATP-NAD
FT                                kinase 2.
FT                                /FTId=PRO_0000229675.
SQ   SEQUENCE   302 AA;  33004 MW;  9F084B24648F90DB CRC64;
     MVRKAGLIVN DGKELAVQTA ISVQKKLEKS NYEVVRVSSS GGMVGFANPD QHVRPLGYSN
     CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN TGHLGFLAEA YLSNLEEAID
     KLIIGKWDIE ERKSLIISVM RNEQRRWESL CLNEMALHRE PLTSMCHFEI SIGRHAPVDI
     SADGVILSTP TGSTAYSLSA GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA
     TPERLVMVVD GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVGKP
     NK
//