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Q7V0I8

- NADK2_PROMP

UniProt

Q7V0I8 - NADK2_PROMP

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Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Proton acceptorUniRule annotation
Binding sitei183 – 1831NADUniRule annotation
Binding sitei218 – 2181NAD; via carbonyl oxygenUniRule annotation
Binding sitei252 – 2521NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802NADUniRule annotation
Nucleotide bindingi153 – 1542NADUniRule annotation
Nucleotide bindingi194 – 1996NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-1304-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:PMM1269
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302NAD kinase 2PRO_0000229675Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM1269.

Structurei

3D structure databases

ProteinModelPortaliQ7V0I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiPRKTKFV.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7V0I8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRKAGLIVN DGKELAVQTA ISVQKKLEKS NYEVVRVSSS GGMVGFANPD
60 70 80 90 100
QHVRPLGYSN CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN
110 120 130 140 150
TGHLGFLAEA YLSNLEEAID KLIIGKWDIE ERKSLIISVM RNEQRRWESL
160 170 180 190 200
CLNEMALHRE PLTSMCHFEI SIGRHAPVDI SADGVILSTP TGSTAYSLSA
210 220 230 240 250
GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA TPERLVMVVD
260 270 280 290 300
GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVGKP

NK
Length:302
Mass (Da):33,004
Last modified:October 1, 2003 - v1
Checksum:i9F084B24648F90DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE19728.1.
RefSeqiNP_893386.1. NC_005072.1.
WP_011132903.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE19728; CAE19728; PMM1269.
GeneIDi1726270.
KEGGipmm:PMM1269.
PATRICi23033596. VBIProMar68066_1455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX548174 Genomic DNA. Translation: CAE19728.1 .
RefSeqi NP_893386.1. NC_005072.1.
WP_011132903.1. NC_005072.1.

3D structure databases

ProteinModelPortali Q7V0I8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59919.PMM1269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE19728 ; CAE19728 ; PMM1269 .
GeneIDi 1726270.
KEGGi pmm:PMM1269.
PATRICi 23033596. VBIProMar68066_1455.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi PRKTKFV.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PMAR59919:GJMQ-1304-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiNADK2_PROMP
AccessioniPrimary (citable) accession number: Q7V0I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3