Reviewed, UniProtKB/Swiss-Prot Q7V0I8 (PPNK2_PROMP)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 2
      Short name=Poly(P)/ATP NAD kinase 2
    EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	PMM1269

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]

Taxonomic identifier

59919 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229675

Sequences

	Sequence		Length	Mass (Da)
	Q7V0I8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9F084B24648F90DB	FASTA	302	33,004
	10 20 30 40 50 60 MVRKAGLIVN DGKELAVQTA ISVQKKLEKS NYEVVRVSSS GGMVGFANPD QHVRPLGYSN 70 80 90 100 110 120 CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN TGHLGFLAEA YLSNLEEAID 130 140 150 160 170 180 KLIIGKWDIE ERKSLIISVM RNEQRRWESL CLNEMALHRE PLTSMCHFEI SIGRHAPVDI 190 200 210 220 230 240 SADGVILSTP TGSTAYSLSA GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA 250 260 270 280 290 300 TPERLVMVVD GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVGKP NK

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX548174 Genomic DNA. Translation: CAE19728.1.
RefSeq	NP_893386.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1726270.
GenomeReviews	Gene locus PMM1269 in contig BX548174_GR.
KEGG	pmm:PMM1269.
NMPDR	fig|59919.1.peg.1265.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7V0I8.
OMA	Q7V0I8. NDGKELA.
Enzyme and pathway databases
BioCyc	PMAR167540:PMM1269-MON.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK2_PROMP

Accession

Primary (citable) accession number: Q7V0I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)