Q7V0I8 (PPNK2_PROMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase 2
Short name=Poly(P)/ATP NAD kinase 2
EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	PMM1269

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]

Taxonomic identifier

59919 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus › Prochlorococcus marinus › Prochlorococcus marinus subsp. pastoris

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP-Rule MF_00361
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD metabolic process Inferred from electronic annotation. Source: InterPro NADP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP-Rule MF_00361		PRO_0000229675

Sequences

	Sequence		Length	Mass (Da)
	Q7V0I8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9F084B24648F90DB	FASTA	302	33,004
	10 20 30 40 50 60 MVRKAGLIVN DGKELAVQTA ISVQKKLEKS NYEVVRVSSS GGMVGFANPD QHVRPLGYSN 70 80 90 100 110 120 CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN TGHLGFLAEA YLSNLEEAID 130 140 150 160 170 180 KLIIGKWDIE ERKSLIISVM RNEQRRWESL CLNEMALHRE PLTSMCHFEI SIGRHAPVDI 190 200 210 220 230 240 SADGVILSTP TGSTAYSLSA GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA 250 260 270 280 290 300 TPERLVMVVD GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVGKP NK

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CCMP1986 / MED4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX548174 Genomic DNA. Translation: CAE19728.1.
RefSeq	NP_893386.1. NC_005072.1.
3D structure databases
ProteinModelPortal	Q7V0I8.
ModBase	Search...
Protein-protein interaction databases
STRING	59919.PMM1269.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE19728; CAE19728; PMM1269.
GeneID	1726270.
KEGG	pmm:PMM1269.
PATRIC	23033596. VBIProMar68066_1455.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HOG000227222.
KO	K00858.
OMA	FANPDQH.
ProtClustDB	PRK02649.
Enzyme and pathway databases
BioCyc	PMAR59919:GJMQ-1304-MONOMER.
Family and domain databases
Gene3D	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAP	MF_00361. NAD_kinase.
InterPro	IPR017438. ATP-NAD_kinase_dom_1. IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. PolyP/ATP_NADK_prd. [Graphical view]
PANTHER	PTHR20275. PTHR20275. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK2_PROMP

Accession

Primary (citable) accession number: Q7V0I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program