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Q7V0I8

- NADK2_PROMP

UniProt

Q7V0I8 - NADK2_PROMP

Protein

NAD kinase 2

Gene

nadK2

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791Proton acceptorUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei218 – 2181NAD; via carbonyl oxygenUniRule annotation
    Binding sitei252 – 2521NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 802NADUniRule annotation
    Nucleotide bindingi153 – 1542NADUniRule annotation
    Nucleotide bindingi194 – 1996NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMAR59919:GJMQ-1304-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:PMM1269
    OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
    Taxonomic identifieri59919 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000001026: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302NAD kinase 2PRO_0000229675Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59919.PMM1269.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7V0I8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiPRKTKFV.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7V0I8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKAGLIVN DGKELAVQTA ISVQKKLEKS NYEVVRVSSS GGMVGFANPD    50
    QHVRPLGYSN CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN 100
    TGHLGFLAEA YLSNLEEAID KLIIGKWDIE ERKSLIISVM RNEQRRWESL 150
    CLNEMALHRE PLTSMCHFEI SIGRHAPVDI SADGVILSTP TGSTAYSLSA 200
    GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA TPERLVMVVD 250
    GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVGKP 300
    NK 302
    Length:302
    Mass (Da):33,004
    Last modified:October 1, 2003 - v1
    Checksum:i9F084B24648F90DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548174 Genomic DNA. Translation: CAE19728.1.
    RefSeqiNP_893386.1. NC_005072.1.

    Genome annotation databases

    EnsemblBacteriaiCAE19728; CAE19728; PMM1269.
    GeneIDi1726270.
    KEGGipmm:PMM1269.
    PATRICi23033596. VBIProMar68066_1455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX548174 Genomic DNA. Translation: CAE19728.1 .
    RefSeqi NP_893386.1. NC_005072.1.

    3D structure databases

    ProteinModelPortali Q7V0I8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59919.PMM1269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE19728 ; CAE19728 ; PMM1269 .
    GeneIDi 1726270.
    KEGGi pmm:PMM1269.
    PATRICi 23033596. VBIProMar68066_1455.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi PRKTKFV.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci PMAR59919:GJMQ-1304-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCMP1986 / MED4.

    Entry informationi

    Entry nameiNADK2_PROMP
    AccessioniPrimary (citable) accession number: Q7V0I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3