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Q7V0F6 (DDL_PROMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:PMM1306
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177854

Regions

Domain143 – 350208ATP-grasp
Nucleotide binding178 – 23356ATP By similarity

Sites

Metal binding3031Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 2 By similarity
Metal binding3191Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7V0F6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 1D9780D61F09FCE7

FASTA35539,975
        10         20         30         40         50         60 
MLEKEKKCIG IIFGGESNEH DVSVSSAKTV FKALISKTNI NRFWVKAFYI NKHGVWLDND 

        70         80         90        100        110        120 
QSLVLLKEKR KNETIDKNQV FPKREINFLN TIEFQGIDIW FPLLHGVNGE DGAIHGLLKF 

       130        140        150        160        170        180 
TQKPIVGGGI LGSALGMDKI LMKKIFSHLE IPQVNYLDIQ NQDLSDDKVK NNLSVEIIEK 

       190        200        210        220        230        240 
LKLPVFVKPA NSGSSLGISK AKTRSEIIKA LQKAWEIDSR IVIEEGLDVR ELECGIIGNL 

       250        260        270        280        290        300 
KLTASEIGEV SYSTDWYDYD SKYSMDNQII IPADIDSQIS EQIKDIAIRS CRALNIYGFA 

       310        320        330        340        350 
RVDFFLEKIS NKIFLNEINT IPGFTSKSMF PMLWNASGLN IDQLVAKLVD ISSDL 

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX548174 Genomic DNA. Translation: CAE19765.1.
RefSeqNP_893423.1. NC_005072.1.

3D structure databases

ProteinModelPortalQ7V0F6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59919.PMM1306.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE19765; CAE19765; PMM1306.
GeneID1727034.
KEGGpmm:PMM1306.
PATRIC23033676. VBIProMar68066_1493.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMADVRELEC.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycPMAR59919:GJMQ-1343-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_PROMP
AccessionPrimary (citable) accession number: Q7V0F6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways