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Q7V0C6 (Q7V0C6_PROMP) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138 EMBL CAE19799.1
Ordered Locus Names:PMM1340
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP] EMBL CAE19799.1
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus ›

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain123 – 328206ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding149 – 20961ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2981Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding3001Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
Q7V0C6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: E2575774EF0CCBEB

FASTA44549,311
        10         20         30         40         50         60 
MSINTINSKS SNKLENILII GNGGRENALA WAIQKNDLIK KIYLLPGNAG SKKINKSERI 

        70         80         90        100        110        120 
NLDLKNTKVL TSKLKFLNID LIVIGPETPL AEGLGEVLRR NNFDVFGPGP DGAKLESSKS 

       130        140        150        160        170        180 
WAKEFMKDAN IPTANFWKVK SLKEAKKIIF TSPNPLVVKA DGLASGKGVF IPESKEASIN 

       190        200        210        220        230        240 
ATEEIFKGKF GNAGEIIVLE EKIEGPEVSV FALCDGKKYV LLPTAQDHKR LNENDKGPNT 

       250        260        270        280        290        300 
GGMGAYSPTP MMTKSLLETI TKEIIEPTIN SLLRKNIDYK GVLYFGLMIT KSGPKVIEYN 

       310        320        330        340        350        360 
CRFGDPECQT IMPLMDKDFV ILLQKCAKGN LLGNEKIKMS NKFSGCVIAT SKGYPHNYKK 

       370        380        390        400        410        420 
GFPITYGNID YEHCQIFDSG TSLNSKGEFI TDGGRVLSIV CQGEDFNKVF EKAYKNLKEI 

       430        440 
SFDGIYYRKD IGHQVRIKKI AERTN

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References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548174 Genomic DNA. Translation: CAE19799.1.
RefSeqNP_893457.1. NC_005072.1.

3D structure databases

HSSPHSSP built from PDB template 1GSO based on UniProtKB P15640.
ProteinModelPortalQ7V0C6.
ModBaseSearch...

Protein-protein interaction databases

STRING59919.PMM1340.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE19799; CAE19799; PMM1340.
GeneID1726862.
KEGGpmm:PMM1340.
PATRIC23033748. VBIProMar68066_1528.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAMGAYTPL.
ProtClustDBCLSK922154.

Enzyme and pathway databases

BioCycPMAR59919:GJMQ-1379-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7V0C6_PROMP
AccessionPrimary (citable) accession number: Q7V0C6
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info