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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADUniRule annotation
Binding sitei189 – 1891NADUniRule annotation
Binding sitei212 – 2121NADUniRule annotation
Binding sitei235 – 2351SubstrateUniRule annotation
Metal bindingi257 – 2571ZincUniRule annotation
Binding sitei257 – 2571SubstrateUniRule annotation
Metal bindingi260 – 2601ZincUniRule annotation
Binding sitei260 – 2601SubstrateUniRule annotation
Active sitei325 – 3251Proton acceptorUniRule annotation
Active sitei326 – 3261Proton acceptorUniRule annotation
Binding sitei326 – 3261SubstrateUniRule annotation
Metal bindingi359 – 3591ZincUniRule annotation
Binding sitei359 – 3591SubstrateUniRule annotation
Binding sitei413 – 4131SubstrateUniRule annotation
Metal bindingi418 – 4181ZincUniRule annotation
Binding sitei418 – 4181SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-1528-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PMM1488
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenasePRO_0000135816Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM1488.

Structurei

3D structure databases

ProteinModelPortaliQ7V004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7V004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIINSKQKA LQELRRISQR TTSGDNKKIN SIVENILQEV KFHGDIAVEK
60 70 80 90 100
YTKKFDGFYP KPMQVSTRDL KTAWEETDQH LKKSLEVAYQ RIKKFHEKEI
110 120 130 140 150
PESFTIKGEF GDSVQRRWMP VKNAGLYIPG GRAAYPSTVL MNAIPAKVAG
160 170 180 190 200
VKEISMVSPG NEKGKINTTV LAAAYLSGVD KVFRIGGAQA IGALAFGTKQ
210 220 230 240 250
INKVDVISGP GNIYVTTAKK LIYGFTGIDS LAGPSEILII ADRTANSSQI
260 270 280 290 300
ASDLLAQAEH DPLASSILLT TSNDQAQEVF DEVFKIIENH PRKEICIQSI
310 320 330 340 350
KNWGLIAICE NLESCVELSN EFAPEHLEII TIDPKTTLKS IENAGAIFLG
360 370 380 390 400
KWTPEAVGDY LAGPNHTLPT CGNARFSGSL GVETFMKNSS IIEFNEKSLK
410 420
INSVDIINLA NSEGLHSHAN SVKIRFED
Length:428
Mass (Da):47,022
Last modified:September 30, 2003 - v1
Checksum:i2037539E408759D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE19947.1.
RefSeqiNP_893605.1. NC_005072.1.
WP_011133116.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE19947; CAE19947; PMM1488.
KEGGipmm:PMM1488.
PATRICi23034154. VBIProMar68066_1730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE19947.1.
RefSeqiNP_893605.1. NC_005072.1.
WP_011133116.1. NC_005072.1.

3D structure databases

ProteinModelPortaliQ7V004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59919.PMM1488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE19947; CAE19947; PMM1488.
KEGGipmm:PMM1488.
PATRICi23034154. VBIProMar68066_1730.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciPMAR59919:GJMQ-1528-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiHISX_PROMP
AccessioniPrimary (citable) accession number: Q7V004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2004
Last sequence update: September 30, 2003
Last modified: March 31, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.