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Q7V004 (HISX_PROMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:PMM1488
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 428428Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135816

Sites

Active site3251Proton acceptor By similarity
Active site3261Proton acceptor By similarity
Metal binding2571Zinc By similarity
Metal binding2601Zinc By similarity
Metal binding3591Zinc By similarity
Metal binding4181Zinc By similarity
Binding site1271NAD By similarity
Binding site1891NAD By similarity
Binding site2121NAD By similarity
Binding site2351Substrate By similarity
Binding site2571Substrate By similarity
Binding site2601Substrate By similarity
Binding site3261Substrate By similarity
Binding site3591Substrate By similarity
Binding site4131Substrate By similarity
Binding site4181Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7V004 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2037539E408759D6

FASTA42847,022
        10         20         30         40         50         60 
MKIINSKQKA LQELRRISQR TTSGDNKKIN SIVENILQEV KFHGDIAVEK YTKKFDGFYP 

        70         80         90        100        110        120 
KPMQVSTRDL KTAWEETDQH LKKSLEVAYQ RIKKFHEKEI PESFTIKGEF GDSVQRRWMP 

       130        140        150        160        170        180 
VKNAGLYIPG GRAAYPSTVL MNAIPAKVAG VKEISMVSPG NEKGKINTTV LAAAYLSGVD 

       190        200        210        220        230        240 
KVFRIGGAQA IGALAFGTKQ INKVDVISGP GNIYVTTAKK LIYGFTGIDS LAGPSEILII 

       250        260        270        280        290        300 
ADRTANSSQI ASDLLAQAEH DPLASSILLT TSNDQAQEVF DEVFKIIENH PRKEICIQSI 

       310        320        330        340        350        360 
KNWGLIAICE NLESCVELSN EFAPEHLEII TIDPKTTLKS IENAGAIFLG KWTPEAVGDY 

       370        380        390        400        410        420 
LAGPNHTLPT CGNARFSGSL GVETFMKNSS IIEFNEKSLK INSVDIINLA NSEGLHSHAN 


SVKIRFED 

« Hide

References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX548174 Genomic DNA. Translation: CAE19947.1.
RefSeqNP_893605.1. NC_005072.1.

3D structure databases

ProteinModelPortalQ7V004.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59919.PMM1488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE19947; CAE19947; PMM1488.
GeneID1725608.
KEGGpmm:PMM1488.
PATRIC23034154. VBIProMar68066_1730.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAETFMKHS.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

BioCycPMAR59919:GJMQ-1528-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_PROMP
AccessionPrimary (citable) accession number: Q7V004
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways