Reviewed, UniProtKB/Swiss-Prot Q7UZS3 (HEM6_PROMP)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	PMM1582

Organism

Prochlorococcus marinus subsp. pastoris (strain CCMP1378 / MED4) [Complete proteome] [HAMAP]

Taxonomic identifier

59919 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109909

Sequences

	Sequence		Length	Mass (Da)
	Q7UZS3-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: F9D874BAA3B7FB7F	FASTA	342	39,848
	10 20 30 40 50 60 MSKEPPKNSR EKTKNLLLKL QDNICKGLEN IDGKAKFTEE SWLREEGGGG KSRVLKNGSI 70 80 90 100 110 120 FEQAGVNFSE VHGKELPQSI ISQRPEAKGH KWFATGTSMV LHPKNPFIPT VHLNYRYFEA 130 140 150 160 170 180 GPVWWFGGGA DLTPYYPYLT DVRNFHKEHC NACEKVNKNL HKVFKPWCDE YFFLKHRNES 190 200 210 220 230 240 RGIGGIFYDY QDGSGRIYKG NNKESKAYKE SINIGELNLN WNNLFSLAEN CGGAFLDSYQ 250 260 270 280 290 300 PIIEKRVNQN YTKEQREFQL YRRGRYVEFN LVWDRGTIFG LQTNGRTESI LMSLPPLARW 310 320 330 340 EYGYKAKKGS REDYLTKIFT KPQDWQNDKI LEKFCKENNI FD

References

[1]

"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation." Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W. Nature 424:1042-1047(2003) [PubMed: 12917642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX548174 Genomic DNA. Translation: CAE20041.1.
RefSeq	NP_893699.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1726476.
GenomeReviews	Gene locus PMM1582 in contig BX548174_GR.
KEGG	pmm:PMM1582.
NMPDR	fig|59919.1.peg.1578.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7UZS3.
Enzyme and pathway databases
BioCyc	PMAR167540:PMM1582-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_PROMP

Accession

Primary (citable) accession number: Q7UZS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	November 4, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)