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Q7UZR6

- PANCY_PROMP

UniProt

Q7UZR6 - PANCY_PROMP

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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
ATP + (d)CMP = ADP + (d)CDP.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi289 – 2979ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59919:GJMQ-1634-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:PMM1590
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000001026: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Bifunctional pantoate ligase/cytidylate kinasePRO_0000239792Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM1590.

Structurei

3D structure databases

ProteinModelPortaliQ7UZR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 276276Pantoate--beta-alanine ligaseAdd
BLAST
Regioni277 – 510234Cytidylate kinaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.Curated
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UZR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKIIIRKTE DLKEWRRNLK CDINFIPTMG NLHDGHQKLI STAQSSNCNT
60 70 80 90 100
NLLSIFVNPL QFDSKEDLKS YPKTVDKDIE IAFSNGADAI FIPNVTDIYP
110 120 130 140 150
KKNKSISYLK ASKELSSALC GLTRVGHFDG VCTVVYRLLK LIQPKNLFLG
160 170 180 190 200
EKDWQQLLII KNLIEEKKFN IKIIPVPTQR DSDGVPFSSR NKHLSKSERK
210 220 230 240 250
SLKLFSNELE NAKIIFKKDK RIDLKQLTNK LKSKNISIEY LEHLHPYSLK
260 270 280 290 300
KVQSNDNISI LAGAIKCGKT RLIDHVFLMK RKPIIAIDGP AGSGKSTITK
310 320 330 340 350
LIAKELNLLY LDTGAMYRAI SWLFKKEKID YAKESELKKI LNNISIIFKS
360 370 380 390 400
NSISQQDVFI NNFCVTEEIR SQEISSIVSK ISSIKKVREF LVYEQRKIGQ
410 420 430 440 450
SGGLVAEGRD IGTTVFPNAE LKIFLTASID ERAKRRKSEL DLRGTEEIDF
460 470 480 490 500
NQLRELIRKR DFEDSTRKIS PLKKANDAIE LLTDGYSINE VVEKIVNIYN
510
LNIPKEIQLE
Length:510
Mass (Da):58,295
Last modified:October 1, 2003 - v1
Checksum:i315DC94E014CBDF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE20049.1.
RefSeqiNP_893707.1. NC_005072.1.

Genome annotation databases

EnsemblBacteriaiCAE20049; CAE20049; PMM1590.
GeneIDi1726235.
KEGGipmm:PMM1590.
PATRICi23034364. VBIProMar68066_1831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE20049.1 .
RefSeqi NP_893707.1. NC_005072.1.

3D structure databases

ProteinModelPortali Q7UZR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59919.PMM1590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE20049 ; CAE20049 ; PMM1590 .
GeneIDi 1726235.
KEGGi pmm:PMM1590.
PATRICi 23034364. VBIProMar68066_1831.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci PMAR59919:GJMQ-1634-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCMP1986 / MED4.

Entry informationi

Entry nameiPANCY_PROMP
AccessioniPrimary (citable) accession number: Q7UZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3