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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:PMM1709
OrganismiProchlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)
Taxonomic identifieri59919 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001026 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalUniRule annotationAdd BLAST21
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei82 – 102HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 123HelicalUniRule annotationAdd BLAST21
Transmembranei147 – 167HelicalUniRule annotationAdd BLAST21
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Transmembranei203 – 223HelicalUniRule annotationAdd BLAST21
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088701 – 359Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST359

Interactioni

Protein-protein interaction databases

STRINGi59919.PMM1709.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UZF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIGKTRSLT FTSLFFLLVI SLIVNSYIFN SLLIINIFLI SSLISLVITK
60 70 80 90 100
YGFKIISRLN LLQNIRSEGP SLHFNKTNTP TMGGIFIILP FLLLLLIVNN
110 120 130 140 150
YVDSVGILLL FFCTISFFII GFLDDYLSIA NKKNAGLKSN EKFTLQALIA
160 170 180 190 200
VLFIIFASQS NYINPLITIS NNWNMDTNIV IFPICFLTLV GLSNAVNLTD
210 220 230 240 250
GLDGLAAGCS AIVFFGLGTE IFIKGQKDLI IYGLISYAMS GLCIGFLKYN
260 270 280 290 300
KYPAKIFMGD TGSLTIGAAL GSISILTNSF FTLFIISGIF ITEALSVMIQ
310 320 330 340 350
VSFFKITKKL FKKGKRVFLM TPIHHHFELK GIKEEKIVEN FWKVNILLIV

LGIVLKINL
Length:359
Mass (Da):39,947
Last modified:October 1, 2003 - v1
Checksum:iF690632A2C5F86D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX548174 Genomic DNA. Translation: CAE20168.1.

Genome annotation databases

EnsemblBacteriaiCAE20168; CAE20168; PMM1709.
KEGGipmm:PMM1709.

Similar proteinsi

Entry informationi

Entry nameiMRAY_PROMP
AccessioniPrimary (citable) accession number: Q7UZF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families