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Q7UZF8 (MRAY_PROMP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:PMM1709
OrganismProchlorococcus marinus subsp. pastoris (strain CCMP1986 / MED4) [Complete proteome] [HAMAP]
Taxonomic identifier59919 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorales › Prochlorococcaceae › Prochlorococcus ›

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_0000108870

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane28 – 4821Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane256 – 27621Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane337 – 35721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7UZF8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F690632A2C5F86D1

FASTA35939,947
        10         20         30         40         50         60 
MMIGKTRSLT FTSLFFLLVI SLIVNSYIFN SLLIINIFLI SSLISLVITK YGFKIISRLN 

        70         80         90        100        110        120 
LLQNIRSEGP SLHFNKTNTP TMGGIFIILP FLLLLLIVNN YVDSVGILLL FFCTISFFII 

       130        140        150        160        170        180 
GFLDDYLSIA NKKNAGLKSN EKFTLQALIA VLFIIFASQS NYINPLITIS NNWNMDTNIV 

       190        200        210        220        230        240 
IFPICFLTLV GLSNAVNLTD GLDGLAAGCS AIVFFGLGTE IFIKGQKDLI IYGLISYAMS 

       250        260        270        280        290        300 
GLCIGFLKYN KYPAKIFMGD TGSLTIGAAL GSISILTNSF FTLFIISGIF ITEALSVMIQ 

       310        320        330        340        350 
VSFFKITKKL FKKGKRVFLM TPIHHHFELK GIKEEKIVEN FWKVNILLIV LGIVLKINL

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References

[1]"Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation."
Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A., Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L., Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C. expand/collapse author list , Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R., Chisholm S.W.
Nature 424:1042-1047(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CCMP1986 / MED4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX548174 Genomic DNA. Translation: CAE20168.1.
RefSeqNP_893826.1. NC_005072.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING59919.PMM1709.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE20168; CAE20168; PMM1709.
GeneID1727289.
KEGGpmm:PMM1709.
PATRIC23034608. VBIProMar68066_1950.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275124.
KOK01000.
OMAEYLTQFY.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycPMAR59919:GJMQ-1757-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PTHR22926:SF3. PTHR22926:SF3. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_PROMP
AccessionPrimary (citable) accession number: Q7UZF8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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