Q7UXK9 (DNAE2_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase
EC=2.7.7.7

Gene names

Name:	dnaE2
Ordered Locus Names:	RB1262

Organism

Rhodopirellula baltica (strain SH1)

Taxonomic identifier

243090 [NCBI]

Taxonomic lineage

Bacteria › Planctomycetes › Planctomycetacia › Planctomycetales › Planctomycetaceae › Rhodopirellula

Protein attributes

Sequence length	1145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902
Subcellular location	Cytoplasm By similarity HAMAP MF_01902.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Cellular component	Cytoplasm
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1145	1145	Error-prone DNA polymerase HAMAP MF_01902		PRO_0000103397

Sequences

	Sequence		Length	Mass (Da)
	Q7UXK9 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 10FAB7E2DB99B878	FASTA	1,145	128,627
	10 20 30 40 50 60 MCSWRCAAAR SHASANRCTP KERLGRQENR SAHCPGTIRS IRMEWSRWER QEFRCKRSFQ 70 80 90 100 110 120 RLGSSCEQFS PPMQNRRWEI ERLPWRFSPV GKPFHFRDNV RAMRYVELHC RSNFSFLDGA 130 140 150 160 170 180 SHPDELVQRA AELGYEGLAI TDRESIAGVV RGFSPAQELG LQYIVGTEVH PTDAPPMVLW 190 200 210 220 230 240 PTDRAAYGRM CRMLSTGRMR CEKGRCELSF EDIAEHAQGI LAGVIATDES RSIEDQHAHV 250 260 270 280 290 300 NDSRQFLRGP FRDVFDDRGY LLASFHRGVD DAAKATWLRN LSLATDVPLL ACGDVRYHSA 310 320 330 340 350 360 ERMALHDCVV AISQGKSVEQ IQSDRLVNSQ HHLRSLEEIA ELYRDVPDAV ARTIEVAQRC 370 380 390 400 410 420 TFTLDQLKYE YPVELAPEGM TPIEHLKRLT WEGARGRWPN GVPEKVIETL RHEVTLIEDL 430 440 450 460 470 480 QYEAYFLTVW DLVRFARSQE ILCQGRGSAA NSVVCYCLGI TSVDPTHTDL LFERFISRER 490 500 510 520 530 540 GEAPDIDVDF EHQRREEVLQ YLYEKYGRDR AGMTAVVTCY RAKSAIREVG KALAISPDII 550 560 570 580 590 600 DAVAKLAGSY SRNPELPERC RDAGLDPDTP LGRRFLYLTE TLIGFPRHLS QHVGGMVMTA 610 620 630 640 650 660 GSLCELCVTE NAAMPGRSVI QWNKDDLDDI GILKVDILAL GMLSAIRRCF ELVKDHHNRE 670 680 690 700 710 720 LSLSTIPPDD TPTYDMICAA DTMGVFQIES RAQMSMLPRL KPRCYYDLVI EVAIVRPGPI 730 740 750 760 770 780 QGNMVHPFLA ARENPAAAKY PNDAIRKVLE KTLGVPIFQE QAMKLAVVAA GFTPGEADQL 790 800 810 820 830 840 RRAMAAWRRP GVIDRFRTKL LEGMKANGLN GEFAENVFRQ IRGFGEYGFP ESHAASFALL 850 860 870 880 890 900 VYASCYLKRH YPTAFCAALL DSQPMGFYAP AQLIRDAQQH GVQVLPVDIN DSNIRSKLIP 910 920 930 940 950 960 DLNRPHPKLR LGLQMVRGLP SAVAQKIIVA RDANGPFANL HDLTTRAKLS RSNIATLADA 970 980 990 1000 1010 1020 DALASIAQDR RAAVWQSLAQ DDSGDSMPLL ADLEPDCSVP EELVPMSPAE EVKNDYATTG 1030 1040 1050 1060 1070 1080 LSLKAHPVSF WRDDLNALRC KRASDLPKLR DGVHVRVAGL VLMRQRPGTA KGITFVTMED 1090 1100 1110 1120 1130 1140 ETGSMNLVLF AQVWKRFFKI ARGSDAWIVD GKLENKKGVI HVIVGRVEDL SEKASGLKVP RRDFR

References

[1]

"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1." Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R. Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed: 12835416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SH1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX294135 Genomic DNA. Translation: CAD71997.1.
RefSeq	NP_864318.1. NC_005027.1.
3D structure databases
ProteinModelPortal	Q7UXK9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1791510.
GenomeReviews	Gene locus RB1262 in contig BX119912_GR.
KEGG	rba:RB1262.
NMPDR	fig|243090.1.peg.659.
PATRIC	23242573. VBIRhoBal59814_0577.
Phylogenomic databases
HOGENOM	HBG734490.
OMA	MFQIESP.
PhylomeDB	Q7UXK9.
ProtClustDB	CLSK2758575.
Enzyme and pathway databases
BioCyc	PSP117:RB1262-MONOMER.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DNAE2_RHOBA

Accession

Primary (citable) accession number: Q7UXK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program