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Q7UX39

- HISX_RHOBA

UniProt

Q7UX39 - HISX_RHOBA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei269 – 2691SubstrateUniRule annotation
    Metal bindingi291 – 2911ZincUniRule annotation
    Binding sitei291 – 2911SubstrateUniRule annotation
    Metal bindingi294 – 2941ZincUniRule annotation
    Binding sitei294 – 2941SubstrateUniRule annotation
    Active sitei358 – 3581Proton acceptorUniRule annotation
    Active sitei359 – 3591Proton acceptorUniRule annotation
    Binding sitei359 – 3591SubstrateUniRule annotation
    Metal bindingi392 – 3921ZincUniRule annotation
    Binding sitei392 – 3921SubstrateUniRule annotation
    Binding sitei446 – 4461SubstrateUniRule annotation
    Metal bindingi451 – 4511ZincUniRule annotation
    Binding sitei451 – 4511SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:RB1584
    OrganismiRhodopirellula baltica (strain SH1)
    Taxonomic identifieri243090 [NCBI]
    Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
    ProteomesiUP000001025: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Histidinol dehydrogenasePRO_0000135834Add
    BLAST

    Proteomic databases

    PRIDEiQ7UX39.

    Interactioni

    Protein-protein interaction databases

    STRINGi243090.RB1584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7UX39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7UX39-1 [UniParc]FASTAAdd to Basket

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    MFRIVAVPEF SIQTVDARDP SSSEAAETLA ALREKLSPRG DLVSPRGREL    50
    TLKVFGKALS PIEVVETICK DVQSQGTEAL LRYTKSLDGA ELTADTLRVP 100
    EEDLKAAHAV ADPKLIETIG RIRDNIATFQ SAILHRDVTI TPRPGVSLTQ 150
    RYVPIPRVGI CVPGGAAAYP STVMMTAIPA QVAGVDEIAV VAPPTPFGAY 200
    NTDMLATCHE LGIKEVYRCG GAQAVAAMAY GCDALPAVDK IVGPGNLFVA 250
    LAKKHVFGTV DIDSFAGPSE VIVIADESAN AAFVASDLLA QAEHSPGSAI 300
    LITWDESLLT SVQAELSRQL GELERGDLAR DALSDFGALV LARDADHACE 350
    LTDSFAPEHL QIETREPESL IAKIRHSGAA FLGHHTPVAL GDYAAGPSHV 400
    LPTGGTCRWA AGLSANSFLR SGSVTQFDQS ALSAIAQDVI TVAEKEGLTA 450
    HARSISIRTE 460
    Length:460
    Mass (Da):48,514
    Last modified:October 1, 2003 - v1
    Checksum:i507E4E5DAE69E1BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294135 Genomic DNA. Translation: CAD72173.1.
    RefSeqiNP_864492.1. NC_005027.1.

    Genome annotation databases

    EnsemblBacteriaiCAD72173; CAD72173; RB1584.
    GeneIDi1789901.
    KEGGirba:RB1584.
    PATRICi23242901. VBIRhoBal59814_0740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294135 Genomic DNA. Translation: CAD72173.1 .
    RefSeqi NP_864492.1. NC_005027.1.

    3D structure databases

    ProteinModelPortali Q7UX39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243090.RB1584.

    Proteomic databases

    PRIDEi Q7UX39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD72173 ; CAD72173 ; RB1584 .
    GeneIDi 1789901.
    KEGGi rba:RB1584.
    PATRICi 23242901. VBIRhoBal59814_0740.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH1.

    Entry informationi

    Entry nameiHISX_RHOBA
    AccessioniPrimary (citable) accession number: Q7UX39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3