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Q7UX39

- HISX_RHOBA

UniProt

Q7UX39 - HISX_RHOBA

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei269 – 2691SubstrateUniRule annotation
Metal bindingi291 – 2911ZincUniRule annotation
Binding sitei291 – 2911SubstrateUniRule annotation
Metal bindingi294 – 2941ZincUniRule annotation
Binding sitei294 – 2941SubstrateUniRule annotation
Active sitei358 – 3581Proton acceptorUniRule annotation
Active sitei359 – 3591Proton acceptorUniRule annotation
Binding sitei359 – 3591SubstrateUniRule annotation
Metal bindingi392 – 3921ZincUniRule annotation
Binding sitei392 – 3921SubstrateUniRule annotation
Binding sitei446 – 4461SubstrateUniRule annotation
Metal bindingi451 – 4511ZincUniRule annotation
Binding sitei451 – 4511SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:RB1584
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Histidinol dehydrogenasePRO_0000135834Add
BLAST

Proteomic databases

PRIDEiQ7UX39.

Interactioni

Protein-protein interaction databases

STRINGi243090.RB1584.

Structurei

3D structure databases

ProteinModelPortaliQ7UX39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ7UX39.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UX39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRIVAVPEF SIQTVDARDP SSSEAAETLA ALREKLSPRG DLVSPRGREL
60 70 80 90 100
TLKVFGKALS PIEVVETICK DVQSQGTEAL LRYTKSLDGA ELTADTLRVP
110 120 130 140 150
EEDLKAAHAV ADPKLIETIG RIRDNIATFQ SAILHRDVTI TPRPGVSLTQ
160 170 180 190 200
RYVPIPRVGI CVPGGAAAYP STVMMTAIPA QVAGVDEIAV VAPPTPFGAY
210 220 230 240 250
NTDMLATCHE LGIKEVYRCG GAQAVAAMAY GCDALPAVDK IVGPGNLFVA
260 270 280 290 300
LAKKHVFGTV DIDSFAGPSE VIVIADESAN AAFVASDLLA QAEHSPGSAI
310 320 330 340 350
LITWDESLLT SVQAELSRQL GELERGDLAR DALSDFGALV LARDADHACE
360 370 380 390 400
LTDSFAPEHL QIETREPESL IAKIRHSGAA FLGHHTPVAL GDYAAGPSHV
410 420 430 440 450
LPTGGTCRWA AGLSANSFLR SGSVTQFDQS ALSAIAQDVI TVAEKEGLTA
460
HARSISIRTE
Length:460
Mass (Da):48,514
Last modified:October 1, 2003 - v1
Checksum:i507E4E5DAE69E1BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294135 Genomic DNA. Translation: CAD72173.1.
RefSeqiNP_864492.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD72173; CAD72173; RB1584.
GeneIDi1789901.
KEGGirba:RB1584.
PATRICi23242901. VBIRhoBal59814_0740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294135 Genomic DNA. Translation: CAD72173.1 .
RefSeqi NP_864492.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UX39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB1584.

Proteomic databases

PRIDEi Q7UX39.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD72173 ; CAD72173 ; RB1584 .
GeneIDi 1789901.
KEGGi rba:RB1584.
PATRICi 23242901. VBIRhoBal59814_0740.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
InParanoidi Q7UX39.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiHISX_RHOBA
AccessioniPrimary (citable) accession number: Q7UX39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3