Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7UWB8

- NADK_RHOBA

UniProt

Q7UWB8 - NADK_RHOBA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene

nadK

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Binding sitei190 – 1901NADUniRule annotation
Binding sitei192 – 1921NADUniRule annotation
Binding sitei200 – 2001NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 892NADUniRule annotation
Nucleotide bindingi162 – 1632NADUniRule annotation
Nucleotide bindingi203 – 2086NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:RB2142
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311NAD kinasePRO_0000226303Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB2142.

Structurei

3D structure databases

ProteinModelPortaliQ7UWB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
InParanoidiQ7UWB8.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UWB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRSRFRGRI TGWYLMASSS GEKLDWCGCG RPPRIVVLGA PDKLNVSSAW
60 70 80 90 100
KRLRPTIQSH AELIAADFEF TYDFSDKEVD LVIVIGGDGS ILQSARQMGE
110 120 130 140 150
NQTPVLGINC GRLGFLAALS PEDFLDAWPK VCQGDFSIIR HLMLEVQLIR
160 170 180 190 200
DDEVIAQSMA LNEAAILNGP PFAILDIDLY ADGELATQYR CDGLIVATPV
210 220 230 240 250
GSTAHNLSAG GPILRRQLQA IVISPISPHT LTYRPLVDSA DTRLELAVTE
260 270 280 290 300
PNESTSIVVD GRILGQLKSG DRVRVHRAPV SFEMLRVPGQ NDYRTLREKL
310
GWSGRLALRQ L
Length:311
Mass (Da):34,205
Last modified:October 1, 2003 - v1
Checksum:i57FFFD5C35CAD00D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294136 Genomic DNA. Translation: CAD72448.1.
RefSeqiNP_864763.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD72448; CAD72448; RB2142.
GeneIDi1796044.
KEGGirba:RB2142.
PATRICi23243383. VBIRhoBal59814_0978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294136 Genomic DNA. Translation: CAD72448.1 .
RefSeqi NP_864763.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UWB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB2142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD72448 ; CAD72448 ; RB2142 .
GeneIDi 1796044.
KEGGi rba:RB2142.
PATRICi 23243383. VBIRhoBal59814_0978.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
InParanoidi Q7UWB8.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiNADK_RHOBA
AccessioniPrimary (citable) accession number: Q7UWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3