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Protein

dCTP deaminase

Gene

dcd

Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Proton donor/acceptorUniRule annotation1
Binding sitei144dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 104dCTP bindingUniRule annotation6
Nucleotide bindingi125 – 127dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciRBAL243090:G1GTC-1865-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:RB3427
OrganismiRhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
Proteomesi
  • UP000001025 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560071 – 198dCTP deaminaseAdd BLAST198

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi243090.RB3427

Structurei

3D structure databases

ProteinModelPortaliQ7UU94
SMRiQ7UU94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UUT Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
InParanoidiQ7UU94
KOiK01494
OMAiGWIDAGF
OrthoDBiPOG091H021I

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

Q7UU94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKETPIMILS GQDIQSRLGK DIVIDPFDPS RLSPNSYNLT LHDELLVYEE
60 70 80 90 100
VVLDAASPNR YRRLPIPEEG LTLQPGTLYL GRTTEHTETH GLVPIIQGRS
110 120 130 140 150
SLGRLGLFLN PGGSLGHAGY RGTWTLELHC VQPVRIYPHI QICQITYWEV
160 170 180 190
SGDSPEEASE KYQNSNDIQP SLMHRELGYD DRDTQLELGF DEAIRSTP
Length:198
Mass (Da):22,297
Last modified:October 1, 2003 - v1
Checksum:iEA6E2385CF3627BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294138 Genomic DNA Translation: CAD73188.1
RefSeqiNP_865504.1, NC_005027.1
WP_011119358.1, NC_005027.1

Genome annotation databases

EnsemblBacteriaiCAD73188; CAD73188; RB3427
GeneIDi1793506
KEGGirba:RB3427
PATRICifig|243090.15.peg.1582

Similar proteinsi

Entry informationi

Entry nameiDCD_RHOBA
AccessioniPrimary (citable) accession number: Q7UU94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health