Q7UTQ8 (PANC_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate synthetase
Short name=PS
EC=6.3.2.1

Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	RB3735

Organism

Rhodopirellula baltica (strain SH1)

Taxonomic identifier

243090 [NCBI]

Taxonomic lineage

Bacteria › Planctomycetes › Planctomycetacia › Planctomycetales › Planctomycetaceae › Rhodopirellula

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP MF_00158
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158
Subunit structure	Homodimer By similarity. HAMAP MF_00158
Subcellular location	Cytoplasm Potential HAMAP MF_00158.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP MF_00158
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Pantothenate synthetase HAMAP MF_00158		PRO_0000305531
Regions
	Nucleotide binding	30 – 37	8	ATP By similarity
	Nucleotide binding	150 – 153	4	ATP By similarity
	Nucleotide binding	187 – 190	4	ATP By similarity
Sites
	Active site	37	1	Proton donor By similarity
	Binding site	61	1	Beta-alanine By similarity
	Binding site	61	1	Pantoate By similarity
	Binding site	156	1	Pantoate By similarity
	Binding site	179	1	ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7UTQ8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 4A99472A7608B58E	FASTA	283	31,265
	10 20 30 40 50 60 METFTSIDAM RAWCREKSRG GNTIGLVPTM GALHEGHLSL VHAAKKDCDH CVTSIFVNPT 70 80 90 100 110 120 QFAANEDLDQ YPRPIEDDLA MLRDAGVEAV FMPTADEMYP GGPQTHATSV HPSAVAFPLE 130 140 150 160 170 180 GVHRPEHFVG VATVVMKLFQ AAPSDRAFFG RKDLQQLCVI EHMVRDLNLP IEIVPCDIVR 190 200 210 220 230 240 EPDGLAMSSR NRYLSDDQRQ RALCISKSLN QVEQAFLEGN HDPKQLESIM ADHLSPCDSV 250 260 270 280 DYAVVVDRQT LLPISEITQN AVALVAVRVG VTRLIDNREL IVA

References

[1]

"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1." Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R. Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed: 12835416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SH1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX294139 Genomic DNA. Translation: CAD73378.1.
RefSeq	NP_865693.1. NC_005027.1.
3D structure databases
HSSP	HSSP built from PDB template 2A84 based on UniProtKB P0A5R0.
ProteinModelPortal	Q7UTQ8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1796897.
GenomeReviews	Gene locus RB3735 in contig BX119912_GR.
KEGG	rba:RB3735.
NMPDR	fig|243090.1.peg.2033.
PATRIC	23244907. VBIRhoBal59814_1737.
Phylogenomic databases
HOGENOM	HBG428839.
OMA	EMDGLAM.
PhylomeDB	Q7UTQ8.
Enzyme and pathway databases
BioCyc	PSP117:RB3735-MONOMER.
Family and domain databases
HAMAP	MF_00158. PanC. [Tree]
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01918.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. PanC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_RHOBA

Accession

Primary (citable) accession number: Q7UTQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program