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Q7US71

- RUVC_RHOBA

UniProt

Q7US71 - RUVC_RHOBA

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Protein
Crossover junction endodeoxyribonuclease RuvC
Gene
ruvC, RB4673
Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Magnesium By similarity
Metal bindingi80 – 801Magnesium By similarity
Metal bindingi154 – 1541Magnesium By similarity
Metal bindingi157 – 1571Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:RB4673
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Crossover junction endodeoxyribonuclease RuvCUniRule annotation
PRO_0000183127Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB4673.

Structurei

3D structure databases

ProteinModelPortaliQ7US71.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012182.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7US71-1 [UniParc]FASTAAdd to Basket

« Hide

MGTQVVTARP GSASCILGID PGLNTTGYAV ISREGPRLCL REAGVIKSRR    50
SDTLPERLRE IHVGLSEVFA VHAVDLMALE QLFSHYDRPR TAILMGHARG 100
VICLAAASAG VPVEHYEPTR VKKVMTGNGR APKSQIQLAV KMQLNLQSVP 150
EPADVADAMA ISLCGHYLAN NPIDQALA 178
Length:178
Mass (Da):19,046
Last modified:October 1, 2003 - v1
Checksum:i55EC30C8276A95A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294140 Genomic DNA. Translation: CAD73926.1.
RefSeqiNP_866240.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD73926; CAD73926; RB4673.
GeneIDi1797025.
KEGGirba:RB4673.
PATRICi23245827. VBIRhoBal59814_2195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294140 Genomic DNA. Translation: CAD73926.1 .
RefSeqi NP_866240.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7US71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB4673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD73926 ; CAD73926 ; RB4673 .
GeneIDi 1797025.
KEGGi rba:RB4673.
PATRICi 23245827. VBIRhoBal59814_2195.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012182.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiRUVC_RHOBA
AccessioniPrimary (citable) accession number: Q7US71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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