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Q7UQA4 (SYW_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:RB6436
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136668

Regions

Motif9 – 179"HIGH" region HAMAP-Rule MF_00140
Motif189 – 1935"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1921ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7UQA4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F185D2350B7F523C

FASTA32035,533
        10         20         30         40         50         60 
MRVLSGIQPT GRPHWGNYFG AIRQYIDLQE DNEGFYFIAD LHALTTVREP EVLRENVMNA 

        70         80         90        100        110        120 
ALDLLALGLD PSKANLFVQS DIPEVTELTW LLMTGTPMGL LERCHAFKEK KAKGLTADAG 

       130        140        150        160        170        180 
LFTYPVLMAA DILAYDSQIV PVGVDQVQHI EVCRDLAGSF HHAFGETFVL PKAKTLDVGA 

       190        200        210        220        230        240 
KVPGTDGQKM SKSYNNTLPL FGEVKKIRKQ IMRIVTDSRP MEDPKDPTDD HLFQLYQLFA 

       250        260        270        280        290        300 
GPAEVETMAA KYRAGGFGYG EIKKAVAEVS EEYFAPARAK REELESDLDT VRDILAEGAK 

       310        320 
RAREVAASVV DRARRNCGLR 

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294144 Genomic DNA. Translation: CAD74801.1.
RefSeqNP_867255.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UQA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243090.RB6436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD74801; CAD74801; RB6436.
GeneID1791723.
KEGGrba:RB6436.
PATRIC23247675. VBIRhoBal59814_3112.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMALELYWIL.
OrthoDBEOG686NJQ.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_RHOBA
AccessionPrimary (citable) accession number: Q7UQA4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries