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Q7UQA4

- SYW_RHOBA

UniProt

Q7UQA4 - SYW_RHOBA

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:RB6436
    OrganismiRhodopirellula baltica (strain SH1)
    Taxonomic identifieri243090 [NCBI]
    Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
    ProteomesiUP000001025: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Tryptophan--tRNA ligasePRO_0000136668Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243090.RB6436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7UQA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi9 – 179"HIGH" region
    Motifi189 – 1935"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059939.
    KOiK01867.
    OMAiLELYWIL.
    OrthoDBiEOG686NJQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7UQA4-1 [UniParc]FASTAAdd to Basket

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    MRVLSGIQPT GRPHWGNYFG AIRQYIDLQE DNEGFYFIAD LHALTTVREP    50
    EVLRENVMNA ALDLLALGLD PSKANLFVQS DIPEVTELTW LLMTGTPMGL 100
    LERCHAFKEK KAKGLTADAG LFTYPVLMAA DILAYDSQIV PVGVDQVQHI 150
    EVCRDLAGSF HHAFGETFVL PKAKTLDVGA KVPGTDGQKM SKSYNNTLPL 200
    FGEVKKIRKQ IMRIVTDSRP MEDPKDPTDD HLFQLYQLFA GPAEVETMAA 250
    KYRAGGFGYG EIKKAVAEVS EEYFAPARAK REELESDLDT VRDILAEGAK 300
    RAREVAASVV DRARRNCGLR 320
    Length:320
    Mass (Da):35,533
    Last modified:October 1, 2003 - v1
    Checksum:iF185D2350B7F523C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294144 Genomic DNA. Translation: CAD74801.1.
    RefSeqiNP_867255.1. NC_005027.1.

    Genome annotation databases

    EnsemblBacteriaiCAD74801; CAD74801; RB6436.
    GeneIDi1791723.
    KEGGirba:RB6436.
    PATRICi23247675. VBIRhoBal59814_3112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294144 Genomic DNA. Translation: CAD74801.1 .
    RefSeqi NP_867255.1. NC_005027.1.

    3D structure databases

    ProteinModelPortali Q7UQA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243090.RB6436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD74801 ; CAD74801 ; RB6436 .
    GeneIDi 1791723.
    KEGGi rba:RB6436.
    PATRICi 23247675. VBIRhoBal59814_3112.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059939.
    KOi K01867.
    OMAi LELYWIL.
    OrthoDBi EOG686NJQ.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH1.

    Entry informationi

    Entry nameiSYW_RHOBA
    AccessioniPrimary (citable) accession number: Q7UQA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3