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Q7UPZ8 (PUR2_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:RB6616
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence caution

The sequence CAD74908.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151475

Regions

Domain110 – 322213ATP-grasp
Nucleotide binding142 – 20362ATP By similarity

Sites

Metal binding2921Magnesium or manganese By similarity
Metal binding2941Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7UPZ8 [UniParc].

Last modified February 7, 2006. Version 2.
Checksum: FF709E7F10A19993

FASTA43746,501
        10         20         30         40         50         60 
MSKYNVLIVG SGGREHALAW KVKQSQHVQN VFVAPGNAGT GMDATNVDLD PADHDAVIQF 

        70         80         90        100        110        120 
AKENNVGLVI VGPEAPLVAG LVDALTDAGL RAFGPSKAAS ELEGSKVFCK NLLRSADIPT 

       130        140        150        160        170        180 
ADYRTFRSAD DASRYIKDRF SEPTDPVNVV VKADGLAAGK GVVVCDTRSE ALEAIDRIAA 

       190        200        210        220        230        240 
RKEFGAAGKE LIIEERLTGP EVSVLAITDG ETIVTLPPAQ DHKPANDGDT GPNTGGMGAY 

       250        260        270        280        290        300 
CPAPVLDEET LAKVESSILV PVVHAMKRSR RPFKGVLYAG LMLTPAGPKV LEFNVRFGDP 

       310        320        330        340        350        360 
ECQPLLMRLK TDLVEVMQAV VDGKLEETGP LEFDPRPAIC VVMASEGYPA DYEKGHAITG 

       370        380        390        400        410        420 
IESADKMENV KVFHAGTQRV DGEVVNTGGR VLGVTAMGDS ISAAKLQAYK AVREIRWQGA 

       430 
WCRKDISDKA LVTADKA 

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294144 Genomic DNA. Translation: CAD74908.1. Different initiation.
RefSeqNP_867362.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UPZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243090.RB6616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD74908; CAD74908; RB6616.
GeneID1795089.
KEGGrba:RB6616.
PATRIC23247859. VBIRhoBal59814_3204.

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OrthoDBEOG69SKD1.
ProtClustDBCLSK2759121.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_RHOBA
AccessionPrimary (citable) accession number: Q7UPZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways