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Q7UPM9

- GSA_RHOBA

UniProt

Q7UPM9 - GSA_RHOBA

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, RB6831
Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:RB6831
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000226305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243090.RB6831.

Structurei

3D structure databases

ProteinModelPortaliQ7UPM9.
SMRiQ7UPM9. Positions 15-436.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UPM9-1 [UniParc]FASTAAdd to Basket

« Hide

MNSPANSSAA RPAAGPKSVA AFQRASALMP GGVNSPARAF GAVGGTPLFI    50
ERAEGPYLYD IDGNRYIDYI GSWGPMILGH AHPEVINAIT QAAAKGTSYG 100
APTEAESRLA EQIIEAVPSI EKVRLVNSGT EATMSALRVA RGATGRKKVI 150
KFAGNYHGHV DSLLVAAGSA AATLGAPDSP GVTPGAAEDT LVLSYNDVSG 200
LQNAFAQHGD DIAALILEPV VGNMGCVLPT MEFLNAARDL TTKHGSILIF 250
DEVMTGFRVA YGGAQERFGV TPDMTTLGKI VGGGMPLGAY GGRADIMNQV 300
LPAGKVFQAG TLSGNPVAVA AGSATLRLLK ENPPYEQLER LADRLADGLD 350
RAATSAGMAH TVAKAGAMLT LFFNPEPVDC WAVADRCDRE AFGRYFWGLI 400
DEGIYMPCSQ FEALFFSQQH TEAMIDETIA AAEKVLKSL 439
Length:439
Mass (Da):45,935
Last modified:October 1, 2003 - v1
Checksum:i52F7D89E87373ADD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294144 Genomic DNA. Translation: CAD75032.1.
RefSeqiNP_867486.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD75032; CAD75032; RB6831.
GeneIDi1790380.
KEGGirba:RB6831.
PATRICi23248081. VBIRhoBal59814_3315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294144 Genomic DNA. Translation: CAD75032.1 .
RefSeqi NP_867486.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UPM9.
SMRi Q7UPM9. Positions 15-436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB6831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD75032 ; CAD75032 ; RB6831 .
GeneIDi 1790380.
KEGGi rba:RB6831.
PATRICi 23248081. VBIRhoBal59814_3315.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiGSA_RHOBA
AccessioniPrimary (citable) accession number: Q7UPM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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