Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciRBAL243090:G1GTC-3857-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:RB6831
OrganismiRhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
Proteomesi
  • UP000001025 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002263051 – 439Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ7UPM9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243090.RB6831

Structurei

3D structure databases

ProteinModelPortaliQ7UPM9
SMRiQ7UPM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
InParanoidiQ7UPM9
KOiK01845
OMAiVIAEACP
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7UPM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPANSSAA RPAAGPKSVA AFQRASALMP GGVNSPARAF GAVGGTPLFI
60 70 80 90 100
ERAEGPYLYD IDGNRYIDYI GSWGPMILGH AHPEVINAIT QAAAKGTSYG
110 120 130 140 150
APTEAESRLA EQIIEAVPSI EKVRLVNSGT EATMSALRVA RGATGRKKVI
160 170 180 190 200
KFAGNYHGHV DSLLVAAGSA AATLGAPDSP GVTPGAAEDT LVLSYNDVSG
210 220 230 240 250
LQNAFAQHGD DIAALILEPV VGNMGCVLPT MEFLNAARDL TTKHGSILIF
260 270 280 290 300
DEVMTGFRVA YGGAQERFGV TPDMTTLGKI VGGGMPLGAY GGRADIMNQV
310 320 330 340 350
LPAGKVFQAG TLSGNPVAVA AGSATLRLLK ENPPYEQLER LADRLADGLD
360 370 380 390 400
RAATSAGMAH TVAKAGAMLT LFFNPEPVDC WAVADRCDRE AFGRYFWGLI
410 420 430
DEGIYMPCSQ FEALFFSQQH TEAMIDETIA AAEKVLKSL
Length:439
Mass (Da):45,935
Last modified:October 1, 2003 - v1
Checksum:i52F7D89E87373ADD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294144 Genomic DNA Translation: CAD75032.1
RefSeqiNP_867486.1, NC_005027.1
WP_007331929.1, NC_005027.1

Genome annotation databases

EnsemblBacteriaiCAD75032; CAD75032; RB6831
GeneIDi1790380
KEGGirba:RB6831
PATRICifig|243090.15.peg.3315

Similar proteinsi

Entry informationi

Entry nameiGSA_RHOBA
AccessioniPrimary (citable) accession number: Q7UPM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health