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Q7UPM4 (KPRS_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Synonyms:prsA
Ordered Locus Names:RB6844
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteria › Planctomycetes › Planctomycetia › Planctomycetales › Planctomycetaceae › Rhodopirellula ›

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00583.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
PRO_0000141182

Regions

Region214 – 22714Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1281Magnesium Potential
Metal binding1301Magnesium Potential
Metal binding1391Magnesium Potential
Metal binding1431Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q7UPM4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5E252276A91448CF

FASTA31634,778
        10         20         30         40         50         60 
MRELKIFSGR ANHDLAEKLC RHLHLKPARI TLGQFPDGEN YCKLDEDVRG RDVFLVQPTC 

        70         80         90        100        110        120 
PPVNDNLIEL LTMIDCCKRA SAERITAVIP YFGYARQDRK DEGRVPITAK LVANLITRAG 

       130        140        150        160        170        180 
ADRVLTMDLH AAQIQGFFDV PVDHLYAAPV INDHFVSRRF AGDEVVVVSP DEGSIKRALG 

       190        200        210        220        230        240 
HTKRLGGNLA IVDKRRTNAL EVRQNTIIGG PVEGKVALMF DDMISTAGSI CGAARLVHEA 

       250        260        270        280        290        300 
GAKEIHIACT HGVLCGPAIE RLREAPIDSI TVTDTIPVTG EKLLPNLVQL SVAPLLAEAI 

       310 
KRIHHDQSIS ELFRER

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX294145 Genomic DNA. Translation: CAD75037.1.
RefSeqNP_867491.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UPM4.
ModBaseSearch...

Protein-protein interaction databases

STRING243090.RB6844.

Proteomic databases

PRIDEQ7UPM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD75037; CAD75037; RB6844.
GeneID1791957.
KEGGrba:RB6844.
PATRIC23248089. VBIRhoBal59814_3319.

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAYVQIQES.
ProtClustDBCLSK2759150.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_RHOBA
AccessionPrimary (citable) accession number: Q7UPM4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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