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Q7UNQ8 (UPPP_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:RB7435
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151188

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane236 – 25621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7UNQ8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 12A05E90284054EE

FASTA25727,487
        10         20         30         40         50         60 
MQELIRVVIL AIVQGIAEFL PISSSGHLVI LGSMLGELGE SVTLEIILHA GTLGSILVVF 

        70         80         90        100        110        120 
WQRIWALLLK DRRVIGLLVI GTLPAVVIGL TIKTQFPEIL RSPLLAGAML IVTGVMLIVL 

       130        140        150        160        170        180 
GRLTPKSGTY DRLGLGAAFL VGCFQAFAIL PGISRSGSTI LGGRLMGLDR DDSVTFSFLL 

       190        200        210        220        230        240 
AIPAILGATV LAIKDLLEDG SSGETSIEVL SIGAAVAFAV GIVALKWLIR WSREDRLHWF 

       250 
AYWCIPAGLL VVLLNLR 

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294146 Genomic DNA. Translation: CAD75360.1.
RefSeqNP_867813.1. NC_005027.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243090.RB7435.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD75360; CAD75360; RB7435.
GeneID1791742.
KEGGrba:RB7435.
PATRIC23248627. VBIRhoBal59814_3587.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAVIYFRNE.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_RHOBA
AccessionPrimary (citable) accession number: Q7UNQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families