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Q7UNH1

- GCSPB_RHOBA

UniProt

Q7UNH1 - GCSPB_RHOBA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:RB7584
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi243090.RB7584.

Structurei

3D structure databases

ProteinModelPortaliQ7UNH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
InParanoidiQ7UNH1.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UNH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNQQSTQLL FELSRAGRRA HRLGDLDVPS VNVDELFADE ALAETPPPLP
60 70 80 90 100
ELAEGDVVRH FVGLSTLNMS VDTHFYPLGS CTMKYNPKRN ERIASLPGFL
110 120 130 140 150
NVHPLQHESG LQGLLELLYE LQGMFAEISG LPGVSMQPAA GAHGELAALL
160 170 180 190 200
VAAAYFREQG SDRNVVLTAD SAHGTNPASA QMAGFKTKTV KSNANGLVDL
210 220 230 240 250
EDLKAKLDDK TAVFMLTNPN TLGLFDRQIE EINKLVHDAG ALIYLDGANM
260 270 280 290 300
NAILGITRPG DFGADLMHYN PHKTFSGPHG GGGPGAGPIC VRDFLAKYLP
310 320 330 340 350
GPIVTRVENE NASGDDDRYT YHLTSPSDDS IGRVRSFFGN TGVLVRAYIY
360 370 380 390 400
LRTYGGDGLR HVSEDAVLGA NYLLSKVKHF LDVPHGDRCM HEFVASATRL
410 420 430 440 450
KKEKKLSAMD IAKRILDYGF HAPTVYFPLV VDEAVMVEPT ETESKQTLDA
460 470 480 490 500
FVEALFRITE EGEELIHDAP HSTRISRPDD VTAARRPILK WTDAAGESAT
Length:500
Mass (Da):54,548
Last modified:October 1, 2003 - v1
Checksum:iD7976005C686D1D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294146 Genomic DNA. Translation: CAD75448.1.
RefSeqiNP_867901.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD75448; CAD75448; RB7584.
GeneIDi1795707.
KEGGirba:RB7584.
PATRICi23248781. VBIRhoBal59814_3664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294146 Genomic DNA. Translation: CAD75448.1 .
RefSeqi NP_867901.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UNH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB7584.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD75448 ; CAD75448 ; RB7584 .
GeneIDi 1795707.
KEGGi rba:RB7584.
PATRICi 23248781. VBIRhoBal59814_3664.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
InParanoidi Q7UNH1.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiGCSPB_RHOBA
AccessioniPrimary (citable) accession number: Q7UNH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3