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Q7UNH1 (GCSPB_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:RB7584
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167010

Amino acid modifications

Modified residue2731N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7UNH1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D7976005C686D1D4

FASTA50054,548
        10         20         30         40         50         60 
MRNQQSTQLL FELSRAGRRA HRLGDLDVPS VNVDELFADE ALAETPPPLP ELAEGDVVRH 

        70         80         90        100        110        120 
FVGLSTLNMS VDTHFYPLGS CTMKYNPKRN ERIASLPGFL NVHPLQHESG LQGLLELLYE 

       130        140        150        160        170        180 
LQGMFAEISG LPGVSMQPAA GAHGELAALL VAAAYFREQG SDRNVVLTAD SAHGTNPASA 

       190        200        210        220        230        240 
QMAGFKTKTV KSNANGLVDL EDLKAKLDDK TAVFMLTNPN TLGLFDRQIE EINKLVHDAG 

       250        260        270        280        290        300 
ALIYLDGANM NAILGITRPG DFGADLMHYN PHKTFSGPHG GGGPGAGPIC VRDFLAKYLP 

       310        320        330        340        350        360 
GPIVTRVENE NASGDDDRYT YHLTSPSDDS IGRVRSFFGN TGVLVRAYIY LRTYGGDGLR 

       370        380        390        400        410        420 
HVSEDAVLGA NYLLSKVKHF LDVPHGDRCM HEFVASATRL KKEKKLSAMD IAKRILDYGF 

       430        440        450        460        470        480 
HAPTVYFPLV VDEAVMVEPT ETESKQTLDA FVEALFRITE EGEELIHDAP HSTRISRPDD 

       490        500 
VTAARRPILK WTDAAGESAT 

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294146 Genomic DNA. Translation: CAD75448.1.
RefSeqNP_867901.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UNH1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243090.RB7584.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD75448; CAD75448; RB7584.
GeneID1795707.
KEGGrba:RB7584.
PATRIC23248781. VBIRhoBal59814_3664.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAMHINLHK.
OrthoDBEOG6HMXDX.
ProtClustDBPRK04366.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_RHOBA
AccessionPrimary (citable) accession number: Q7UNH1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families