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Q7UNC6

- MDH_RHOBA

UniProt

Q7UNC6 - MDH_RHOBA

Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei85 – 851SubstrateUniRule annotation
    Binding sitei91 – 911SubstrateUniRule annotation
    Binding sitei98 – 981NADUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi121 – 1233NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:RB7652
    OrganismiRhodopirellula baltica (strain SH1)
    Taxonomic identifieri243090 [NCBI]
    Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
    ProteomesiUP000001025: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Malate dehydrogenasePRO_0000113464Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243090.RB7652.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7UNC6.
    SMRiQ7UNC6. Positions 3-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7UNC6-1 [UniParc]FASTAAdd to Basket

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    MRRAKITIVG AGNVGATCAH WCAAAELGDV VLLDIPRTED MPRGKALDLM    50
    QASPIMGFDS NIVGTTDYAD TADSDVIVVT AGLPRKPGMS RDDLLATNAK 100
    IVTSVAEEIK ATSPNAVIIV VSNPLDAMVQ QMFKVTGFEP AKVIGQAGVL 150
    DTARYRTFLA MELGVSVEDI SALLMGGHGD TMVPVPSCTS VGGIPVTQLI 200
    SKERLDEIVD RTRKGGAEIV SLLKTGSAYY APAAACAQMV EAIVKDKKRV 250
    IPVAAYCDSE YGVGGYYVGV PVVLGSGGVE RIIELSLTDE ETKAFQNSVD 300
    AVKSLVSTMD GLLAE 315
    Length:315
    Mass (Da):33,055
    Last modified:October 1, 2003 - v1
    Checksum:i72EEF129992BF436
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294146 Genomic DNA. Translation: CAD75493.1.
    RefSeqiNP_867946.1. NC_005027.1.

    Genome annotation databases

    EnsemblBacteriaiCAD75493; CAD75493; RB7652.
    GeneIDi1794536.
    KEGGirba:RB7652.
    PATRICi23248851. VBIRhoBal59814_3699.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294146 Genomic DNA. Translation: CAD75493.1 .
    RefSeqi NP_867946.1. NC_005027.1.

    3D structure databases

    ProteinModelPortali Q7UNC6.
    SMRi Q7UNC6. Positions 3-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243090.RB7652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD75493 ; CAD75493 ; RB7652 .
    GeneIDi 1794536.
    KEGGi rba:RB7652.
    PATRICi 23248851. VBIRhoBal59814_3699.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH1.

    Entry informationi

    Entry nameiMDH_RHOBA
    AccessioniPrimary (citable) accession number: Q7UNC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3