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Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei98NADUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi121 – 123NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:RB7652
OrganismiRhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
Proteomesi
  • UP000001025 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134641 – 315Malate dehydrogenaseAdd BLAST315

Interactioni

Protein-protein interaction databases

STRINGi243090.RB7652.

Structurei

3D structure databases

ProteinModelPortaliQ7UNC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
InParanoidiQ7UNC6.
KOiK00024.
OMAiTTNQKIM.
OrthoDBiPOG091H02N6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UNC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAKITIVG AGNVGATCAH WCAAAELGDV VLLDIPRTED MPRGKALDLM
60 70 80 90 100
QASPIMGFDS NIVGTTDYAD TADSDVIVVT AGLPRKPGMS RDDLLATNAK
110 120 130 140 150
IVTSVAEEIK ATSPNAVIIV VSNPLDAMVQ QMFKVTGFEP AKVIGQAGVL
160 170 180 190 200
DTARYRTFLA MELGVSVEDI SALLMGGHGD TMVPVPSCTS VGGIPVTQLI
210 220 230 240 250
SKERLDEIVD RTRKGGAEIV SLLKTGSAYY APAAACAQMV EAIVKDKKRV
260 270 280 290 300
IPVAAYCDSE YGVGGYYVGV PVVLGSGGVE RIIELSLTDE ETKAFQNSVD
310
AVKSLVSTMD GLLAE
Length:315
Mass (Da):33,055
Last modified:October 1, 2003 - v1
Checksum:i72EEF129992BF436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294146 Genomic DNA. Translation: CAD75493.1.
RefSeqiNP_867946.1. NC_005027.1.
WP_007325654.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD75493; CAD75493; RB7652.
GeneIDi1794536.
KEGGirba:RB7652.
PATRICi23248851. VBIRhoBal59814_3699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294146 Genomic DNA. Translation: CAD75493.1.
RefSeqiNP_867946.1. NC_005027.1.
WP_007325654.1. NC_005027.1.

3D structure databases

ProteinModelPortaliQ7UNC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243090.RB7652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD75493; CAD75493; RB7652.
GeneIDi1794536.
KEGGirba:RB7652.
PATRICi23248851. VBIRhoBal59814_3699.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
InParanoidiQ7UNC6.
KOiK00024.
OMAiTTNQKIM.
OrthoDBiPOG091H02N6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_RHOBA
AccessioniPrimary (citable) accession number: Q7UNC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: October 5, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.