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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95S-adenosyl-L-methionineUniRule annotation1
Binding sitei120S-adenosyl-L-methionineUniRule annotation1
Binding sitei147S-adenosyl-L-methionineUniRule annotation1
Active sitei175By similarity1
Binding sitei175S-adenosyl-L-methionineUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei211SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRBAL243090:G1GTC-4408-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:RB7807
OrganismiRhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
Proteomesi
  • UP000001025 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713821 – 271tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST271

Interactioni

Protein-protein interaction databases

STRINGi243090.RB7807

Structurei

3D structure databases

ProteinModelPortaliQ7UN36
SMRiQ7UN36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni249 – 252Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41083AB Bacteria
COG0220 LUCA
InParanoidiQ7UN36
KOiK03439
OMAiGHALEYC
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q7UN36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVVAAMRVW NPEEGWANRV GRKREGKIVE ILRRVTMTAH GLSHFPRQLL
60 70 80 90 100
RMPRAALRKP NPALDLDSWL KTPEDLPATI NSQTLFGNDQ PLEIEVGSGK
110 120 130 140 150
GLFIQTESDR RPEHNYFGIE IARKYAAHAA ARLAKRERAN AKMLAGDATP
160 170 180 190 200
LFAVTDEGKR IEDGSLDGVH VYFPDPWWKK RHRKRRVLSH DNILNFSRCL
210 220 230 240 250
RVGGRLHFWT DVLDYFELTV ELIAEIAPEL GVPLPETQRE STHDLDFHTH
260 270
FERRSRKMGI PVYRVCYRKR S
Length:271
Mass (Da):31,306
Last modified:October 1, 2003 - v1
Checksum:i753859A9938FEF65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294146 Genomic DNA Translation: CAD75583.1
RefSeqiNP_868036.1, NC_005027.1
WP_011121589.1, NC_005027.1

Genome annotation databases

EnsemblBacteriaiCAD75583; CAD75583; RB7807
GeneIDi1794343
KEGGirba:RB7807
PATRICifig|243090.15.peg.3769

Entry informationi

Entry nameiTRMB_RHOBA
AccessioniPrimary (citable) accession number: Q7UN36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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