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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation
Binding sitei147 – 1471S-adenosyl-L-methionineUniRule annotation
Active sitei175 – 1751By similarity
Binding sitei175 – 1751S-adenosyl-L-methionineUniRule annotation
Binding sitei179 – 1791SubstrateUniRule annotation
Binding sitei211 – 2111SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:RB7807
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271tRNA (guanine-N(7)-)-methyltransferasePRO_0000171382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB7807.

Structurei

3D structure databases

ProteinModelPortaliQ7UN36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni249 – 2524Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiQ7UN36.
KOiK03439.
OMAiDPWWKKR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UN36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVVAAMRVW NPEEGWANRV GRKREGKIVE ILRRVTMTAH GLSHFPRQLL
60 70 80 90 100
RMPRAALRKP NPALDLDSWL KTPEDLPATI NSQTLFGNDQ PLEIEVGSGK
110 120 130 140 150
GLFIQTESDR RPEHNYFGIE IARKYAAHAA ARLAKRERAN AKMLAGDATP
160 170 180 190 200
LFAVTDEGKR IEDGSLDGVH VYFPDPWWKK RHRKRRVLSH DNILNFSRCL
210 220 230 240 250
RVGGRLHFWT DVLDYFELTV ELIAEIAPEL GVPLPETQRE STHDLDFHTH
260 270
FERRSRKMGI PVYRVCYRKR S
Length:271
Mass (Da):31,306
Last modified:September 30, 2003 - v1
Checksum:i753859A9938FEF65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294146 Genomic DNA. Translation: CAD75583.1.
RefSeqiNP_868036.1. NC_005027.1.

Genome annotation databases

GeneIDi1794343.
KEGGirba:RB7807.
PATRICi23248991. VBIRhoBal59814_3769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294146 Genomic DNA. Translation: CAD75583.1.
RefSeqiNP_868036.1. NC_005027.1.

3D structure databases

ProteinModelPortaliQ7UN36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243090.RB7807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1794343.
KEGGirba:RB7807.
PATRICi23248991. VBIRhoBal59814_3769.

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiQ7UN36.
KOiK03439.
OMAiDPWWKKR.
OrthoDBiEOG6K6VBC.

Enzyme and pathway databases

UniPathwayiUPA00989.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiTRMB_RHOBA
AccessioniPrimary (citable) accession number: Q7UN36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 18, 2004
Last sequence update: September 30, 2003
Last modified: March 31, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.