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Q7UMC0

- SYL_RHOBA

UniProt

Q7UMC0 - SYL_RHOBA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei721 – 7211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RB8919
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligasePRO_0000152072Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB8919.

Structurei

3D structure databases

ProteinModelPortaliQ7UMC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionAdd
BLAST
Motifi718 – 7225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
InParanoidiQ7UMC0.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UMC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRYNPNEIE PRWQAYWDEH HTFATPEKVG KKKRYVLDMF PYPSGDGLHV
60 70 80 90 100
GHPEGYTATD IVSRFARARG ESVLHPMGFD AFGLPAEEHA IKTGEHPRVQ
110 120 130 140 150
TQRNIDNFTR QLKMLGFSYD WDRVLATTDE EYFRWTQWIF GVLYDTWFDH
160 170 180 190 200
DQQKGRPISE LPIPAEVTAE GELEIEQYRD SKRLAYLDDA LVNWCPKLGT
210 220 230 240 250
VLANEEVVDG KSEVGGHPVK RIPLRQWMLR ITDYAERLLD GLDDLDWPTG
260 270 280 290 300
IKKLQSDWIG RSTGGEVDFY LQRGAAGDDT GPFVAFKRAR ESEGFPTDPG
310 320 330 340 350
KDCLRVYTTR PDTLFGATYM VVAPEHPLID VLVKPEQKDE VDAYREKASF
360 370 380 390 400
KSDRERTDGD RAKTGVFTGS YAINPADGRS IPIWVADYVL AGYGTGAIMA
410 420 430 440 450
VPAHDERDFE FAVAFDLPVI PVVDPPADHK QREEILAGKA CFAAEGVAIN
460 470 480 490 500
SGEYDGKTTA EVKAALTAEL AKQGLACEAV NYKLRDWLFS RQRFWGEPFP
510 520 530 540 550
VLHEIDSEGN ATGVRRLVPD DQLPVTLPEL ADFKPHGRPE PPLAKADDDW
560 570 580 590 600
LIVELDGKRY RRETNTMPQW AGSCWYYLRY IDPKNSDALI DPQKEKDWMP
610 620 630 640 650
VDLYVGGAEH AVLHLLYSRF WHKVLFDRGH VTCPEPFGKL VNQGMILGEV
660 670 680 690 700
EFTSFVDPSG KHVSTKDVKK DAEGNRVHKA TGEQVEIVSL TEEQVVKKGE
710 720 730 740 750
GFVLASDASI KVDSRAFKMS KSRGNVVNPD SVVRDYGADS LRLYEMFMGP
760 770 780 790 800
LEATKPWAMN GVGGVRSFLD RVWRMIIDEP EDELKVSDAV VDTACDEEQL
810 820 830 840 850
RVLHQTIRKV TEDNEAMSFN TAIAKMMEFT NHFTRCETRP REAMESFLIL
860 870 880 890 900
LAPYAPHMCE ELWKHLGHNE SISLQPWPKW DEAALVQSSI EIPVQINGKV
910 920 930 940 950
KAKISLSPDA KPNEMGEAAL ADPAVQNAIG DKKVVKTIAV PGRMVNLVVK
Length:950
Mass (Da):107,071
Last modified:October 1, 2003 - v1
Checksum:i7CB553E51E6DA6B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294148 Genomic DNA. Translation: CAD75997.1.
RefSeqiNP_868620.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD75997; CAD75997; RB8919.
GeneIDi1795825.
KEGGirba:RB8919.
PATRICi23250033. VBIRhoBal59814_4279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294148 Genomic DNA. Translation: CAD75997.1 .
RefSeqi NP_868620.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UMC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB8919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD75997 ; CAD75997 ; RB8919 .
GeneIDi 1795825.
KEGGi rba:RB8919.
PATRICi 23250033. VBIRhoBal59814_4279.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
InParanoidi Q7UMC0.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiSYL_RHOBA
AccessioniPrimary (citable) accession number: Q7UMC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3