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Q7UMC0 (SYL_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:RB8919
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 950950Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152072

Regions

Motif41 – 5212"HIGH" region HAMAP-Rule MF_00049
Motif718 – 7225"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7UMC0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7CB553E51E6DA6B6

FASTA950107,071
        10         20         30         40         50         60 
MVRYNPNEIE PRWQAYWDEH HTFATPEKVG KKKRYVLDMF PYPSGDGLHV GHPEGYTATD 

        70         80         90        100        110        120 
IVSRFARARG ESVLHPMGFD AFGLPAEEHA IKTGEHPRVQ TQRNIDNFTR QLKMLGFSYD 

       130        140        150        160        170        180 
WDRVLATTDE EYFRWTQWIF GVLYDTWFDH DQQKGRPISE LPIPAEVTAE GELEIEQYRD 

       190        200        210        220        230        240 
SKRLAYLDDA LVNWCPKLGT VLANEEVVDG KSEVGGHPVK RIPLRQWMLR ITDYAERLLD 

       250        260        270        280        290        300 
GLDDLDWPTG IKKLQSDWIG RSTGGEVDFY LQRGAAGDDT GPFVAFKRAR ESEGFPTDPG 

       310        320        330        340        350        360 
KDCLRVYTTR PDTLFGATYM VVAPEHPLID VLVKPEQKDE VDAYREKASF KSDRERTDGD 

       370        380        390        400        410        420 
RAKTGVFTGS YAINPADGRS IPIWVADYVL AGYGTGAIMA VPAHDERDFE FAVAFDLPVI 

       430        440        450        460        470        480 
PVVDPPADHK QREEILAGKA CFAAEGVAIN SGEYDGKTTA EVKAALTAEL AKQGLACEAV 

       490        500        510        520        530        540 
NYKLRDWLFS RQRFWGEPFP VLHEIDSEGN ATGVRRLVPD DQLPVTLPEL ADFKPHGRPE 

       550        560        570        580        590        600 
PPLAKADDDW LIVELDGKRY RRETNTMPQW AGSCWYYLRY IDPKNSDALI DPQKEKDWMP 

       610        620        630        640        650        660 
VDLYVGGAEH AVLHLLYSRF WHKVLFDRGH VTCPEPFGKL VNQGMILGEV EFTSFVDPSG 

       670        680        690        700        710        720 
KHVSTKDVKK DAEGNRVHKA TGEQVEIVSL TEEQVVKKGE GFVLASDASI KVDSRAFKMS 

       730        740        750        760        770        780 
KSRGNVVNPD SVVRDYGADS LRLYEMFMGP LEATKPWAMN GVGGVRSFLD RVWRMIIDEP 

       790        800        810        820        830        840 
EDELKVSDAV VDTACDEEQL RVLHQTIRKV TEDNEAMSFN TAIAKMMEFT NHFTRCETRP 

       850        860        870        880        890        900 
REAMESFLIL LAPYAPHMCE ELWKHLGHNE SISLQPWPKW DEAALVQSSI EIPVQINGKV 

       910        920        930        940        950 
KAKISLSPDA KPNEMGEAAL ADPAVQNAIG DKKVVKTIAV PGRMVNLVVK 

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294148 Genomic DNA. Translation: CAD75997.1.
RefSeqNP_868620.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UMC0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243090.RB8919.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD75997; CAD75997; RB8919.
GeneID1795825.
KEGGrba:RB8919.
PATRIC23250033. VBIRhoBal59814_4279.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBCLSK2759438.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_RHOBA
AccessionPrimary (citable) accession number: Q7UMC0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries