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Q7UMC0

- SYL_RHOBA

UniProt

Q7UMC0 - SYL_RHOBA

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Protein
Leucine--tRNA ligase
Gene
leuS, RB8919
Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei721 – 7211ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RB8919
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligaseUniRule annotation
PRO_0000152072Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB8919.

Structurei

3D structure databases

ProteinModelPortaliQ7UMC0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5212"HIGH" regionUniRule annotation
Add
BLAST
Motifi718 – 7225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UMC0-1 [UniParc]FASTAAdd to Basket

« Hide

MVRYNPNEIE PRWQAYWDEH HTFATPEKVG KKKRYVLDMF PYPSGDGLHV    50
GHPEGYTATD IVSRFARARG ESVLHPMGFD AFGLPAEEHA IKTGEHPRVQ 100
TQRNIDNFTR QLKMLGFSYD WDRVLATTDE EYFRWTQWIF GVLYDTWFDH 150
DQQKGRPISE LPIPAEVTAE GELEIEQYRD SKRLAYLDDA LVNWCPKLGT 200
VLANEEVVDG KSEVGGHPVK RIPLRQWMLR ITDYAERLLD GLDDLDWPTG 250
IKKLQSDWIG RSTGGEVDFY LQRGAAGDDT GPFVAFKRAR ESEGFPTDPG 300
KDCLRVYTTR PDTLFGATYM VVAPEHPLID VLVKPEQKDE VDAYREKASF 350
KSDRERTDGD RAKTGVFTGS YAINPADGRS IPIWVADYVL AGYGTGAIMA 400
VPAHDERDFE FAVAFDLPVI PVVDPPADHK QREEILAGKA CFAAEGVAIN 450
SGEYDGKTTA EVKAALTAEL AKQGLACEAV NYKLRDWLFS RQRFWGEPFP 500
VLHEIDSEGN ATGVRRLVPD DQLPVTLPEL ADFKPHGRPE PPLAKADDDW 550
LIVELDGKRY RRETNTMPQW AGSCWYYLRY IDPKNSDALI DPQKEKDWMP 600
VDLYVGGAEH AVLHLLYSRF WHKVLFDRGH VTCPEPFGKL VNQGMILGEV 650
EFTSFVDPSG KHVSTKDVKK DAEGNRVHKA TGEQVEIVSL TEEQVVKKGE 700
GFVLASDASI KVDSRAFKMS KSRGNVVNPD SVVRDYGADS LRLYEMFMGP 750
LEATKPWAMN GVGGVRSFLD RVWRMIIDEP EDELKVSDAV VDTACDEEQL 800
RVLHQTIRKV TEDNEAMSFN TAIAKMMEFT NHFTRCETRP REAMESFLIL 850
LAPYAPHMCE ELWKHLGHNE SISLQPWPKW DEAALVQSSI EIPVQINGKV 900
KAKISLSPDA KPNEMGEAAL ADPAVQNAIG DKKVVKTIAV PGRMVNLVVK 950
Length:950
Mass (Da):107,071
Last modified:October 1, 2003 - v1
Checksum:i7CB553E51E6DA6B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294148 Genomic DNA. Translation: CAD75997.1.
RefSeqiNP_868620.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD75997; CAD75997; RB8919.
GeneIDi1795825.
KEGGirba:RB8919.
PATRICi23250033. VBIRhoBal59814_4279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294148 Genomic DNA. Translation: CAD75997.1 .
RefSeqi NP_868620.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UMC0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243090.RB8919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD75997 ; CAD75997 ; RB8919 .
GeneIDi 1795825.
KEGGi rba:RB8919.
PATRICi 23250033. VBIRhoBal59814_4279.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiSYL_RHOBA
AccessioniPrimary (citable) accession number: Q7UMC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi