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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:RB10113
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Bifunctional purine biosynthesis protein PurHPRO_0000192118Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB10113.

Structurei

3D structure databases

ProteinModelPortaliQ7UKJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
InParanoidiQ7UKJ8.
KOiK00602.
OMAiPCGVAEG.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UKJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVVPVRNA LISVSDKMGL ADFAAGLSAA GVTIYSTGGT RAHLEQSGIK
60 70 80 90 100
VEDVAEYTGF PEMLDGRVKT LHPRIFAGIL ARRDLDDHMD TIADHDIEPF
110 120 130 140 150
DLVVVNLYPF AATVSRSGAT RAECIEQIDI GGPSLVRAAA KNHGDVAIAT
160 170 180 190 200
SPEQYGDVLD QLETLGGTTD ELRTQLAAEA FDHTAGYDRA IADYMQGDAV
210 220 230 240 250
GGEFPASMHV SLRRKTQLRY GENPHQRAAL YSDSSDRSAN LVSARQISGK
260 270 280 290 300
ELSYNNLLDL DAALDIARGF AEPAVSVIKH NNPCGAATGD TLSEAVDKAM
310 320 330 340 350
AGDPLSAFGS VIGMNRTLDE ATAEFLCQPG LFIEAIVAPD FEAGAVGLLT
360 370 380 390 400
TKPRWKDNVR LMQVGRLDEP ARKVSRRFIS GGMLVQDADR MVSSPLQWNT
410 420 430 440 450
VTETPVDDDL WDDISFGWEM VRHVKSNAIV LAKDTSLIGV GAGQMSRVDS
460 470 480 490 500
VEISIKKAAE RSEGSILASD AFFPFPDSIE AAAKAGVLAI IQPGGSRRDD
510 520
EVIAACDEHE IAMVFTGRRH FKH
Length:523
Mass (Da):56,202
Last modified:October 1, 2003 - v1
Checksum:i28DEDD894009E924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294150 Genomic DNA. Translation: CAD76635.1.
RefSeqiNP_869249.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD76635; CAD76635; RB10113.
GeneIDi1795643.
KEGGirba:RB10113.
PATRICi23251235. VBIRhoBal59814_4877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294150 Genomic DNA. Translation: CAD76635.1.
RefSeqiNP_869249.1. NC_005027.1.

3D structure databases

ProteinModelPortaliQ7UKJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243090.RB10113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD76635; CAD76635; RB10113.
GeneIDi1795643.
KEGGirba:RB10113.
PATRICi23251235. VBIRhoBal59814_4877.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
InParanoidiQ7UKJ8.
KOiK00602.
OMAiPCGVAEG.
OrthoDBiEOG6QCDFF.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiPUR9_RHOBA
AccessioniPrimary (citable) accession number: Q7UKJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.