Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7UJL3

- IMDH_RHOBA

UniProt

Q7UJL3 - IMDH_RHOBA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

K(+)UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei292 – 2921NADUniRule annotation
Metal bindingi345 – 3451Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi347 – 3471Potassium; via carbonyl oxygenUniRule annotation
Binding sitei348 – 3481IMPUniRule annotation
Active sitei350 – 3501Thioimidate intermediateUniRule annotation
Metal bindingi350 – 3501Potassium; via carbonyl oxygenUniRule annotation
Binding sitei460 – 4601IMPUniRule annotation
Metal bindingi514 – 5141Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi516 – 5161Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi343 – 3453NADUniRule annotation

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenaseUniRule annotation
Short name:
IMPDUniRule annotation
Short name:
IMPDHUniRule annotation
Gene namesi
Name:guaBUniRule annotation
Ordered Locus Names:RB11822
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Inosine-5'-monophosphate dehydrogenasePRO_0000415690Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243090.RB11822.

Structurei

3D structure databases

ProteinModelPortaliQ7UJL3.
SMRiQ7UJL3. Positions 46-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 19657CBS 1UniRule annotationAdd
BLAST
Domaini200 – 25758CBS 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni383 – 3853IMP bindingUniRule annotation
Regioni406 – 4072IMP bindingUniRule annotation
Regioni430 – 4345IMP bindingUniRule annotation

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165755.
InParanoidiQ7UJL3.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UJL3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGASTRFRRQ SGKVPYNSTA ASVIIARFPH RITFGCPRPR GNENGMFDDK
60 70 80 90 100
IGDLGVTFDD VLLQPRYSEV VPSEVDVSSQ MTQRIRLQIP LISSPMDTVT
110 120 130 140 150
ESEMAIALAK EGGLGIVHKN LSVRRQTEEV LKVKRSANGI IVNPVTLNPA
160 170 180 190 200
QKVSAAAELM DRANVSGIPI VEDDRTLAGI LTRRDLRFLE DPDMPISQVM
210 220 230 240 250
TRENLVTAVG NVTLAQAEKI LTEKRVEKLL LIDEERKLTG LITIRDIDMM
260 270 280 290 300
KRYPRACKDP QGRLRVGAAI GVGDYERAES LIGKGVDVLV VDSAHGHSRN
310 320 330 340 350
VIETVREIKQ NKSWDIDVVA GNVATAEGAA DLIAAGADAV KVGIGPGSIC
360 370 380 390 400
TTRVISGIGV PQVTAILSAV KVAQEKNIPV IADGGIRFSG DITKAIAAGA
410 420 430 440 450
STVMIGSLFA GLAESPGKMI LYQGRTFKAY RGMGSMGAMV KGSSDRYRQK
460 470 480 490 500
GTEAGKLVPE GVEGRVPFKG PLSDYAYQLV GGLRAGMGYV GTRTIEELRR
510 520 530
DAKFIRVSAA TVRENHPHDI AITQEAPNYS PDVHSGDAG
Length:539
Mass (Da):57,876
Last modified:October 1, 2003 - v1
Checksum:i7090A0C1A9075141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294154 Genomic DNA. Translation: CAD77245.1.
RefSeqiNP_870170.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77245; CAD77245; RB11822.
GeneIDi1795246.
KEGGirba:RB11822.
PATRICi23252947. VBIRhoBal59814_5703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294154 Genomic DNA. Translation: CAD77245.1 .
RefSeqi NP_870170.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UJL3.
SMRi Q7UJL3. Positions 46-530.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB11822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD77245 ; CAD77245 ; RB11822 .
GeneIDi 1795246.
KEGGi rba:RB11822.
PATRICi 23252947. VBIRhoBal59814_5703.

Phylogenomic databases

HOGENOMi HOG000165755.
InParanoidi Q7UJL3.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiIMDH_RHOBA
AccessioniPrimary (citable) accession number: Q7UJL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3