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Q7UJL3

- IMDH_RHOBA

UniProt

Q7UJL3 - IMDH_RHOBA

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene
guaB, RB11822
Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei292 – 2921NAD By similarity
Metal bindingi345 – 3451Potassium; via carbonyl oxygen By similarity
Metal bindingi347 – 3471Potassium; via carbonyl oxygen By similarity
Binding sitei348 – 3481IMP By similarity
Active sitei350 – 3501Thioimidate intermediate By similarity
Metal bindingi350 – 3501Potassium; via carbonyl oxygen By similarity
Binding sitei460 – 4601IMP By similarity
Metal bindingi514 – 5141Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi516 – 5161Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi343 – 3453NAD By similarity

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:RB11822
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Inosine-5'-monophosphate dehydrogenaseUniRule annotationPRO_0000415690Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243090.RB11822.

Structurei

3D structure databases

ProteinModelPortaliQ7UJL3.
SMRiQ7UJL3. Positions 46-530.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 19657CBS 1Add
BLAST
Domaini200 – 25758CBS 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni383 – 3853IMP binding By similarity
Regioni406 – 4072IMP binding By similarity
Regioni430 – 4345IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165755.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UJL3-1 [UniParc]FASTAAdd to Basket

« Hide

MGASTRFRRQ SGKVPYNSTA ASVIIARFPH RITFGCPRPR GNENGMFDDK    50
IGDLGVTFDD VLLQPRYSEV VPSEVDVSSQ MTQRIRLQIP LISSPMDTVT 100
ESEMAIALAK EGGLGIVHKN LSVRRQTEEV LKVKRSANGI IVNPVTLNPA 150
QKVSAAAELM DRANVSGIPI VEDDRTLAGI LTRRDLRFLE DPDMPISQVM 200
TRENLVTAVG NVTLAQAEKI LTEKRVEKLL LIDEERKLTG LITIRDIDMM 250
KRYPRACKDP QGRLRVGAAI GVGDYERAES LIGKGVDVLV VDSAHGHSRN 300
VIETVREIKQ NKSWDIDVVA GNVATAEGAA DLIAAGADAV KVGIGPGSIC 350
TTRVISGIGV PQVTAILSAV KVAQEKNIPV IADGGIRFSG DITKAIAAGA 400
STVMIGSLFA GLAESPGKMI LYQGRTFKAY RGMGSMGAMV KGSSDRYRQK 450
GTEAGKLVPE GVEGRVPFKG PLSDYAYQLV GGLRAGMGYV GTRTIEELRR 500
DAKFIRVSAA TVRENHPHDI AITQEAPNYS PDVHSGDAG 539
Length:539
Mass (Da):57,876
Last modified:October 1, 2003 - v1
Checksum:i7090A0C1A9075141
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294154 Genomic DNA. Translation: CAD77245.1.
RefSeqiNP_870170.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77245; CAD77245; RB11822.
GeneIDi1795246.
KEGGirba:RB11822.
PATRICi23252947. VBIRhoBal59814_5703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294154 Genomic DNA. Translation: CAD77245.1 .
RefSeqi NP_870170.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UJL3.
SMRi Q7UJL3. Positions 46-530.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB11822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD77245 ; CAD77245 ; RB11822 .
GeneIDi 1795246.
KEGGi rba:RB11822.
PATRICi 23252947. VBIRhoBal59814_5703.

Phylogenomic databases

HOGENOMi HOG000165755.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiIMDH_RHOBA
AccessioniPrimary (citable) accession number: Q7UJL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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