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Q7UJL3

- IMDH_RHOBA

UniProt

Q7UJL3 - IMDH_RHOBA

Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

    Cofactori

    Potassium.UniRule annotation

    Enzyme regulationi

    Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei292 – 2921NADUniRule annotation
    Metal bindingi345 – 3451Potassium; via carbonyl oxygenUniRule annotation
    Metal bindingi347 – 3471Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei348 – 3481IMPUniRule annotation
    Active sitei350 – 3501Thioimidate intermediateUniRule annotation
    Metal bindingi350 – 3501Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei460 – 4601IMPUniRule annotation
    Metal bindingi514 – 5141Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi516 – 5161Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi343 – 3453NADUniRule annotation

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Potassium

    Enzyme and pathway databases

    UniPathwayiUPA00601; UER00295.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
    Short name:
    IMP dehydrogenaseUniRule annotation
    Short name:
    IMPDUniRule annotation
    Short name:
    IMPDHUniRule annotation
    Gene namesi
    Name:guaBUniRule annotation
    Ordered Locus Names:RB11822
    OrganismiRhodopirellula baltica (strain SH1)
    Taxonomic identifieri243090 [NCBI]
    Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
    ProteomesiUP000001025: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Inosine-5'-monophosphate dehydrogenasePRO_0000415690Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243090.RB11822.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7UJL3.
    SMRiQ7UJL3. Positions 46-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini140 – 19657CBS 1UniRule annotationAdd
    BLAST
    Domaini200 – 25758CBS 2UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni383 – 3853IMP bindingUniRule annotation
    Regioni406 – 4072IMP bindingUniRule annotation
    Regioni430 – 4345IMP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family.UniRule annotation
    Contains 2 CBS domains.UniRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    HOGENOMiHOG000165755.
    KOiK00088.
    OMAiHGHSKNI.
    OrthoDBiEOG6GTZPV.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01964. IMPDH.
    InterProiIPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
    PfamiPF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000130. IMPDH. 1 hit.
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7UJL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGASTRFRRQ SGKVPYNSTA ASVIIARFPH RITFGCPRPR GNENGMFDDK    50
    IGDLGVTFDD VLLQPRYSEV VPSEVDVSSQ MTQRIRLQIP LISSPMDTVT 100
    ESEMAIALAK EGGLGIVHKN LSVRRQTEEV LKVKRSANGI IVNPVTLNPA 150
    QKVSAAAELM DRANVSGIPI VEDDRTLAGI LTRRDLRFLE DPDMPISQVM 200
    TRENLVTAVG NVTLAQAEKI LTEKRVEKLL LIDEERKLTG LITIRDIDMM 250
    KRYPRACKDP QGRLRVGAAI GVGDYERAES LIGKGVDVLV VDSAHGHSRN 300
    VIETVREIKQ NKSWDIDVVA GNVATAEGAA DLIAAGADAV KVGIGPGSIC 350
    TTRVISGIGV PQVTAILSAV KVAQEKNIPV IADGGIRFSG DITKAIAAGA 400
    STVMIGSLFA GLAESPGKMI LYQGRTFKAY RGMGSMGAMV KGSSDRYRQK 450
    GTEAGKLVPE GVEGRVPFKG PLSDYAYQLV GGLRAGMGYV GTRTIEELRR 500
    DAKFIRVSAA TVRENHPHDI AITQEAPNYS PDVHSGDAG 539
    Length:539
    Mass (Da):57,876
    Last modified:October 1, 2003 - v1
    Checksum:i7090A0C1A9075141
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294154 Genomic DNA. Translation: CAD77245.1.
    RefSeqiNP_870170.1. NC_005027.1.

    Genome annotation databases

    EnsemblBacteriaiCAD77245; CAD77245; RB11822.
    GeneIDi1795246.
    KEGGirba:RB11822.
    PATRICi23252947. VBIRhoBal59814_5703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294154 Genomic DNA. Translation: CAD77245.1 .
    RefSeqi NP_870170.1. NC_005027.1.

    3D structure databases

    ProteinModelPortali Q7UJL3.
    SMRi Q7UJL3. Positions 46-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243090.RB11822.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD77245 ; CAD77245 ; RB11822 .
    GeneIDi 1795246.
    KEGGi rba:RB11822.
    PATRICi 23252947. VBIRhoBal59814_5703.

    Phylogenomic databases

    HOGENOMi HOG000165755.
    KOi K00088.
    OMAi HGHSKNI.
    OrthoDBi EOG6GTZPV.

    Enzyme and pathway databases

    UniPathwayi UPA00601 ; UER00295 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01964. IMPDH.
    InterProi IPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
    Pfami PF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000130. IMPDH. 1 hit.
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH1.

    Entry informationi

    Entry nameiIMDH_RHOBA
    AccessioniPrimary (citable) accession number: Q7UJL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3