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Protein

Peptide methionine sulfoxide reductase MsrA 1

Gene

msrA1

Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei25UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA 1UniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductase 1UniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1UniRule annotation
Short name:
Peptide Met(O) reductase 1UniRule annotation
Gene namesi
Name:msrA1UniRule annotation
Ordered Locus Names:RB11847
OrganismiRhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
Proteomesi
  • UP000001025 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326641 – 192Peptide methionine sulfoxide reductase MsrA 1Add BLAST192

Interactioni

Protein-protein interaction databases

STRINGi243090.RB11847.

Structurei

3D structure databases

ProteinModelPortaliQ7UJK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107V8H. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263863.
InParanoidiQ7UJK0.
KOiK07304.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UJK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFDSEIVEV KTRPGEEVAT LAGGCFWCTE AVFERMEGVN DVVSGYIGGK
60 70 80 90 100
IKNPNYKQVC GKMTGHAEAV QIYYDPSKTN FEELLKVFFK THDPTTLNRQ
110 120 130 140 150
GADGGPQYRS SIFVHNDEQR EIAKKTMEKL GEEYRDPIVT LIEPATKFYV
160 170 180 190
AEEYHQDYYR RNPNAGYCQA VVAAKVRKFN RNFGDKIKGS GK
Length:192
Mass (Da):21,782
Last modified:April 18, 2006 - v2
Checksum:iB01D9AFCE2ED80D3
GO

Sequence cautioni

The sequence CAD77258 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294154 Genomic DNA. Translation: CAD77258.1. Different initiation.
RefSeqiNP_870183.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77258; CAD77258; RB11847.
GeneIDi1794193.
KEGGirba:RB11847.
PATRICi23252967. VBIRhoBal59814_5713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294154 Genomic DNA. Translation: CAD77258.1. Different initiation.
RefSeqiNP_870183.1. NC_005027.1.

3D structure databases

ProteinModelPortaliQ7UJK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243090.RB11847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD77258; CAD77258; RB11847.
GeneIDi1794193.
KEGGirba:RB11847.
PATRICi23252967. VBIRhoBal59814_5713.

Phylogenomic databases

eggNOGiENOG4107V8H. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263863.
InParanoidiQ7UJK0.
KOiK07304.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA1_RHOBA
AccessioniPrimary (citable) accession number: Q7UJK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.