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Q7UJJ7 (GCH1_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:RB11853
OrganismRhodopirellula baltica (strain SH1) [Reference proteome] [HAMAP]
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119437

Sites

Metal binding1171Zinc By similarity
Metal binding1201Zinc By similarity
Metal binding1881Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7UJJ7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 551D24A13B5AA56A

FASTA22925,410
        10         20         30         40         50         60 
MFRESDNTIA PSNQDLNKPV VDKEQPAERT PFFVDKNAPH NEVDFARIES AVREILEAVG 

        70         80         90        100        110        120 
EDPDRDGLLE TPERVARMYA EMFAGLKSDP GRHLAKVFAE DYDEIVLVRD ISFCSMCEHH 

       130        140        150        160        170        180 
LLPFTGKAHI AYLPSGKVVG LSKLARVVEE VARRPQVQER LTHTVANLIE DRLSARGVAV 

       190        200        210        220 
VVESTHSCMT MRGIRKPGSL CLTSAMRGAF KTDPKSRAEV LGLINRAAS 

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX294154 Genomic DNA. Translation: CAD77261.1.
RefSeqNP_870186.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UJJ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243090.RB11853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD77261; CAD77261; RB11853.
GeneID1793560.
KEGGrba:RB11853.
PATRIC23252973. VBIRhoBal59814_5716.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAYEQIEYA.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_RHOBA
AccessionPrimary (citable) accession number: Q7UJJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways