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Q7UJJ7

- GCH1_RHOBA

UniProt

Q7UJJ7 - GCH1_RHOBA

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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171ZincUniRule annotation
Metal bindingi120 – 1201ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:RB11853
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229GTP cyclohydrolase 1PRO_0000119437Add
BLAST

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi243090.RB11853.

Structurei

3D structure databases

ProteinModelPortaliQ7UJJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
InParanoidiQ7UJJ7.
KOiK01495.
OMAiYEQIEYA.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7UJJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRESDNTIA PSNQDLNKPV VDKEQPAERT PFFVDKNAPH NEVDFARIES
60 70 80 90 100
AVREILEAVG EDPDRDGLLE TPERVARMYA EMFAGLKSDP GRHLAKVFAE
110 120 130 140 150
DYDEIVLVRD ISFCSMCEHH LLPFTGKAHI AYLPSGKVVG LSKLARVVEE
160 170 180 190 200
VARRPQVQER LTHTVANLIE DRLSARGVAV VVESTHSCMT MRGIRKPGSL
210 220
CLTSAMRGAF KTDPKSRAEV LGLINRAAS
Length:229
Mass (Da):25,410
Last modified:October 1, 2003 - v1
Checksum:i551D24A13B5AA56A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294154 Genomic DNA. Translation: CAD77261.1.
RefSeqiNP_870186.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77261; CAD77261; RB11853.
GeneIDi1793560.
KEGGirba:RB11853.
PATRICi23252973. VBIRhoBal59814_5716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294154 Genomic DNA. Translation: CAD77261.1 .
RefSeqi NP_870186.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UJJ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB11853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD77261 ; CAD77261 ; RB11853 .
GeneIDi 1793560.
KEGGi rba:RB11853.
PATRICi 23252973. VBIRhoBal59814_5716.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
InParanoidi Q7UJJ7.
KOi K01495.
OMAi YEQIEYA.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiGCH1_RHOBA
AccessioniPrimary (citable) accession number: Q7UJJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3