Reviewed, UniProtKB/Swiss-Prot Q7UJI2 (MSRA2_RHOBA)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 2
      Short name=Protein-methionine-S-oxide reductase 2
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 2
      Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	RB11878

Organism

Rhodopirellula baltica [Complete proteome] [HAMAP]

Taxonomic identifier

117 [NCBI]

Taxonomic lineage

Bacteria › Planctomycetes › Planctomycetacia › Planctomycetales › Planctomycetaceae › Pirellula

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Peptide methionine sulfoxide reductase msrA 2 HAMAP MF_01401		PRO_0000232665
Sites
	Active site	11	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7UJI2-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: C8C4AEF7F018FFCB	FASTA	168	19,100
	10 20 30 40 50 60 MTERAVLAGG CFWGMQDLIR KLPGIESTRV GYTGGEVPNA TYRNHGNHAE GIEILFDPEK 70 80 90 100 110 120 TSYRQLLEFF FQIHDPTTPN RQGNDRGPSY RSAIYYVDEE QKQIALDTIA DVNASGLWPG 130 140 150 160 KVVTEVEPVS DFWEAEPEHQ DYLEKVPNGY TCHFPRPNWV LPKRAATE

References

[1]

"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1." Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R. Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed: 12835416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX294154 Genomic DNA. Translation: CAD77276.1.
RefSeq	NP_870201.1.
3D structure databases
HSSP	HSSP built from PDB template 1FF3 based on UniProtKB P27110.
SMR	Q7UJI2. Positions 3-164.
ModBase	Search...
Genome annotation databases
GeneID	1790982.
GenomeReviews	Gene locus RB11878 in contig BX119912_GR.
KEGG	rba:RB11878.
NMPDR	fig|243090.1.peg.6541.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7UJI2.
OMA	Q7UJI2. VPNATYR.
Enzyme and pathway databases
BioCyc	PSP117:RB11878-MON.
BRENDA	1.8.4.11. 280490.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_RHOBA

Accession

Primary (citable) accession number: Q7UJI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)