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Q7UID0 (TYSY_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:RB12614
OrganismRhodopirellula baltica (strain SH1)
Taxonomic identifier243090 [NCBI]
Taxonomic lineageBacteria › Planctomycetes › Planctomycetacia › Planctomycetales › Planctomycetaceae › Rhodopirellula

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008

Subunit structure

Homodimer By similarity. HAMAP MF_00008

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Thymidylate synthase HAMAP MF_00008
PRO_0000141010

Sites

Active site1461 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7UID0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 317BE4B0F0AB0732

FASTA26430,191
        10         20         30         40         50         60 
MQGYLQLLDE VLHDGIDRDD RTGVGTRSLF GRQMRFDLAE GFPLLTTKKL HIRSILHELL 

        70         80         90        100        110        120 
WFLRGDTNIG YLKENKVSIW DEWADEAGDL GPVYGHQWRS WEGANGDTVD QIAWVENEIR 

       130        140        150        160        170        180 
TNPRSRRLVV SAWNVADVPK MALPPCHLLF QFYVSGGRLS CQLYQRSADL FLGVPFNIAS 

       190        200        210        220        230        240 
YAMLTSMMAH VTGLKPGEFV HTLGDVHLYS NHFDQAREQL SRTPRPLPTF HIKRDVASVT 

       250        260 
DFQFDDFELT NYDPHPHIKA PVAV

« Hide

References

[1]"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1."
Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R.
Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed: 12835416] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX294155 Genomic DNA. Translation: CAD77684.1.
RefSeqNP_870607.1. NC_005027.1.

3D structure databases

ProteinModelPortalQ7UID0.
SMRQ7UID0. Positions 1-264.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1793491.
GenomeReviewsGene locus RB12614 in contig BX119912_GR.
KEGGrba:RB12614.
NMPDRfig|243090.1.peg.6947.
PATRIC23253781. VBIRhoBal59814_6119.

Phylogenomic databases

HOGENOMHBG588098.
OMARMALAPC.
PhylomeDBQ7UID0.
ProtClustDBPRK01827.

Enzyme and pathway databases

BioCycPSP117:RB12614-MONOMER.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_RHOBA
AccessionPrimary (citable) accession number: Q7UID0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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