Q7UI86 (KDSB_RHOBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase

Gene names

Name:	kdsB
Ordered Locus Names:	RB12690

Organism

Rhodopirellula baltica (strain SH1)

Taxonomic identifier

243090 [NCBI]

Taxonomic lineage

Bacteria › Planctomycetes › Planctomycetacia › Planctomycetales › Planctomycetaceae › Rhodopirellula

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057
Pathway	Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057
Subcellular location	Cytoplasm Potential HAMAP MF_00057.
Sequence similarities	Belongs to the KdsB family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	3-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057		PRO_0000370134

Sequences

	Sequence		Length	Mass (Da)
	Q7UI86 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 34D762169CAA74D4	FASTA	250	27,384
	10 20 30 40 50 60 MKCMIVIPAR LASSRLSQKL LLQAGGKSVL QHTYEAALKS SVAEEVIVAV DDPRLAAEVD 70 80 90 100 110 120 SFGGQARLTS VDCQSGTDRI AEVALMHEDI NILINVQGDE PEIDPKTIDA VAKLLMQHPE 130 140 150 160 170 180 ADIATAACAI KDRERVEDPN CVKAVLGDDH RAITFSRAAV PHPRDGLTDA LLNAEPPNYW 190 200 210 220 230 240 QHIGLYAYRR EFLLWFATQP PGRLEQIEKL EQLRAIEAGK TIVVAPVEAS APGIDTLEDF 250 RAFTARIESQ

References

[1]

"Complete genome sequence of the marine planctomycete Pirellula sp. strain 1." Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W., Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R., Reinhardt R. Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003) [PubMed: 12835416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SH1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX294155 Genomic DNA. Translation: CAD77728.1.
RefSeq	NP_870651.1. NC_005027.1.
3D structure databases
HSSP	HSSP built from PDB template 1VH3 based on UniProtKB P44490.
ProteinModelPortal	Q7UI86.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1793177.
GenomeReviews	Gene locus RB12690 in contig BX119912_GR.
KEGG	rba:RB12690.
NMPDR	fig|243090.1.peg.6991.
PATRIC	23253853. VBIRhoBal59814_6155.
Phylogenomic databases
HOGENOM	HBG637773.
OMA	INVQADE.
PhylomeDB	Q7UI86.
ProtClustDB	PRK05450.
Enzyme and pathway databases
BioCyc	PSP117:RB12690-MONOMER.
Family and domain databases
HAMAP	MF_00057. CMP-KDO_synth. [Tree]
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
KO	K00979.
PANTHER	PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. KdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSB_RHOBA

Accession

Primary (citable) accession number: Q7UI86

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program