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Q7UI59

- PUR5_RHOBA

UniProt

Q7UI59 - PUR5_RHOBA

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, RB12745
Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:RB12745
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000148240Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB12745.

Structurei

3D structure databases

ProteinModelPortaliQ7UI59.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UI59-1 [UniParc]FASTAAdd to Basket

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MASTYKDAGV DLDVYAESMS RLPRLMHRTF SPRVMPSDGG FAGLFRLDFP    50
GKLFARNYEE PVLVSGTDGV GTKLKIAQTM NQHETVGIDL VAMCVNDLIC 100
TGAEPLFFLD YVAMGRDDPA RLERIVQGIS DGCVDGDLAL LGGETAIMPD 150
MYGTDDYDLA GFAVGVVERK RLVDGHLIAP GDVVLGLQAS GLHSNGFSLV 200
RKIIADHGHQ WSDVIDELNQ DTKTPETLAQ VCLRPTKIYV SAIRSIQSHY 250
RVKQVLHGIA HITGGGIEEN LDRILPPGVN AEIDPNAWTP NPIFQWLQQT 300
GDVATSEMRR VFNMGIGMAV VVNEYYAASV ASQVAKAGIE CSPIGRIVEG 350
SSKVVYKEA 359
Length:359
Mass (Da):38,937
Last modified:November 28, 2003 - v2
Checksum:iE8BD8C886B89572C
GO

Sequence cautioni

The sequence CAD77755.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294155 Genomic DNA. Translation: CAD77755.1. Different initiation.
RefSeqiNP_870678.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77755; CAD77755; RB12745.
GeneIDi1792852.
KEGGirba:RB12745.
PATRICi23253901. VBIRhoBal59814_6179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294155 Genomic DNA. Translation: CAD77755.1 . Different initiation.
RefSeqi NP_870678.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UI59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB12745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD77755 ; CAD77755 ; RB12745 .
GeneIDi 1792852.
KEGGi rba:RB12745.
PATRICi 23253901. VBIRhoBal59814_6179.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiPUR5_RHOBA
AccessioniPrimary (citable) accession number: Q7UI59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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