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Q7UI46

- NRDJ_RHOBA

UniProt

Q7UI46 - NRDJ_RHOBA

Protein

Vitamin B12-dependent ribonucleotide reductase

Gene

nrdJ

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    5'-deoxyadenosylcobalamine (coenzyme B12).By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691SubstrateBy similarity
    Binding sitei242 – 2421Substrate; via amide nitrogenBy similarity
    Active sitei420 – 4201Proton acceptorBy similarity
    Active sitei422 – 4221Cysteine radical intermediateBy similarity
    Active sitei424 – 4241Proton acceptorBy similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. cobalt ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW
    4. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    Cobalamin, Cobalt, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin B12-dependent ribonucleotide reductase (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleoside-diphosphate reductase NrdJ
    Gene namesi
    Name:nrdJ
    Ordered Locus Names:RB12762
    OrganismiRhodopirellula baltica (strain SH1)
    Taxonomic identifieri243090 [NCBI]
    Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
    ProteomesiUP000001025: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10401040Vitamin B12-dependent ribonucleotide reductasePRO_0000231655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi214 ↔ 433Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi243090.RB12762.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7UI46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni213 – 2142Substrate bindingBy similarity
    Regioni420 – 4245Substrate bindingBy similarity
    Regioni604 – 6085Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0209.
    HOGENOMiHOG000021771.
    KOiK00525.
    OMAiTAFDIKF.
    OrthoDBiEOG6H4K5F.

    Family and domain databases

    InterProiIPR013678. RNR_2_N.
    IPR000788. RNR_lg_C.
    IPR013344. RNR_NrdJ/NrdZ.
    IPR024434. TSCPD_dom.
    [Graphical view]
    PfamiPF08471. Ribonuc_red_2_N. 1 hit.
    PF02867. Ribonuc_red_lgC. 1 hit.
    PF12637. TSCPD. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7UI46-1 [UniParc]FASTAAdd to Basket

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    MSTVLPESNA TSRIPANDPA LEKVDSEHGV EYAREKFGTA LRGDRAGLKF     50
    ESKFCPDDGR TPFATTAWDL RSAAIKDESG NALFEQTDCE VPASWSQLAT 100
    NVVVSKYFYG DPKNTDERER SVRQLIHRVT RTISDWGLAD GYFDTPEDGE 150
    RFYRDLTWLS LHQHGAFNSP VWFNVGLHAQ YDVEGDMCNW HWDRTENTTA 200
    QPDNPYEYPQ GSACFIQSVD DNMEDIMRLA CSEAMLFKFG SGTGTDLSTI 250
    RSQREKLSGG GTPSGPLSFM RVYDSIAGVV KSGGKTRRAA KMQSLKVWHP 300
    DILEFIECKW AEEKKAHALI REGYDSNFNG EAYASVCFQN ANLSVRLTDD 350
    YMEAVRKNEN FQTRWITDKP TTEPPSYVAK ELLNKMAECA WHCGDPGVQY 400
    DTTINKWHTC PNSGAINASN PCSEYMFLDD TACNLASINL MKFVQQDGSF 450
    DHERFRAACR TFFIAQEILV DHASYPTEPI ARNSHKFRPL GLGYSNLGSV 500
    IMTAGLPYDS DAARGMCGSL TALLHGEANR TSAELASVVG TFDGYVENEA 550
    PMLRVMQMHR DACDQINDDG PAELKEAARE LWDGVLEIGE KYGFRNAQAT 600
    VLAPTGTISF MMDCDTTGIE PDIALVKYKQ LAGGGMLKIV NQTVKLGLKT 650
    LGYDADTIDE ILKYVDANDT IEGAPGLQDE HLAVFDCAFK PANGVRSIGW 700
    RAHITMMAAA QPFLSGAISK TVNMPTDVTP QDIADAYFWG WELGLKAIAI 750
    YRDGSKQSQP LNTKSDEQKA TDAAEAAKVE TVEKIVYKPR RERLPDTRQS 800
    LTHKFSIAGH EGYLCVGLYP DGRPGEMFIT MAKEGSTIGG IMDSFGTALS 850
    IAMQYGVPLE VIVNKFSHTR FEPMGHTSNK DIRIAKSVVD YIARWLGITF 900
    MSGNDYSPSA EGAAKTGGNG PDLTTAPAGA TANNNSPVMA ELRADAGAAV 950
    ALVERATLLA SLQNGVSNGS ATNGHSNGQS AGGSSDGAVA ERAVDGLGGQ 1000
    ADQFSRFQTD APSCDNCGSI TVRNGNCYLC HNCGNSMGCS 1040
    Length:1,040
    Mass (Da):113,464
    Last modified:October 1, 2003 - v1
    Checksum:iD640951F588F5C03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294155 Genomic DNA. Translation: CAD77768.1.
    RefSeqiNP_870691.1. NC_005027.1.

    Genome annotation databases

    EnsemblBacteriaiCAD77768; CAD77768; RB12762.
    GeneIDi1793559.
    KEGGirba:RB12762.
    PATRICi23253911. VBIRhoBal59814_6184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX294155 Genomic DNA. Translation: CAD77768.1 .
    RefSeqi NP_870691.1. NC_005027.1.

    3D structure databases

    ProteinModelPortali Q7UI46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243090.RB12762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD77768 ; CAD77768 ; RB12762 .
    GeneIDi 1793559.
    KEGGi rba:RB12762.
    PATRICi 23253911. VBIRhoBal59814_6184.

    Phylogenomic databases

    eggNOGi COG0209.
    HOGENOMi HOG000021771.
    KOi K00525.
    OMAi TAFDIKF.
    OrthoDBi EOG6H4K5F.

    Family and domain databases

    InterProi IPR013678. RNR_2_N.
    IPR000788. RNR_lg_C.
    IPR013344. RNR_NrdJ/NrdZ.
    IPR024434. TSCPD_dom.
    [Graphical view ]
    Pfami PF08471. Ribonuc_red_2_N. 1 hit.
    PF02867. Ribonuc_red_lgC. 1 hit.
    PF12637. TSCPD. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    TIGRFAMsi TIGR02504. NrdJ_Z. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SH1.

    Entry informationi

    Entry nameiNRDJ_RHOBA
    AccessioniPrimary (citable) accession number: Q7UI46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3