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Q7UI46

- NRDJ_RHOBA

UniProt

Q7UI46 - NRDJ_RHOBA

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Protein

Vitamin B12-dependent ribonucleotide reductase

Gene
nrdJ, RB12762
Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

5'-deoxyadenosylcobalamine (coenzyme B12) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei169 – 1691Substrate By similarity
Binding sitei242 – 2421Substrate; via amide nitrogen By similarity
Active sitei420 – 4201Proton acceptor By similarity
Active sitei422 – 4221Cysteine radical intermediate By similarity
Active sitei424 – 4241Proton acceptor By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. cobalt ion binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW
  4. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

Cobalamin, Cobalt, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12-dependent ribonucleotide reductase (EC:1.17.4.1)
Alternative name(s):
Ribonucleoside-diphosphate reductase NrdJ
Gene namesi
Name:nrdJ
Ordered Locus Names:RB12762
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10401040Vitamin B12-dependent ribonucleotide reductasePRO_0000231655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi214 ↔ 433Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi243090.RB12762.

Structurei

3D structure databases

ProteinModelPortaliQ7UI46.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 2142Substrate binding By similarity
Regioni420 – 4245Substrate binding By similarity
Regioni604 – 6085Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0209.
HOGENOMiHOG000021771.
KOiK00525.
OMAiTAFDIKF.
OrthoDBiEOG6H4K5F.

Family and domain databases

InterProiIPR013678. RNR_2_N.
IPR000788. RNR_lg_C.
IPR013344. RNR_NrdJ/NrdZ.
IPR024434. TSCPD_dom.
[Graphical view]
PfamiPF08471. Ribonuc_red_2_N. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PF12637. TSCPD. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UI46-1 [UniParc]FASTAAdd to Basket

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MSTVLPESNA TSRIPANDPA LEKVDSEHGV EYAREKFGTA LRGDRAGLKF     50
ESKFCPDDGR TPFATTAWDL RSAAIKDESG NALFEQTDCE VPASWSQLAT 100
NVVVSKYFYG DPKNTDERER SVRQLIHRVT RTISDWGLAD GYFDTPEDGE 150
RFYRDLTWLS LHQHGAFNSP VWFNVGLHAQ YDVEGDMCNW HWDRTENTTA 200
QPDNPYEYPQ GSACFIQSVD DNMEDIMRLA CSEAMLFKFG SGTGTDLSTI 250
RSQREKLSGG GTPSGPLSFM RVYDSIAGVV KSGGKTRRAA KMQSLKVWHP 300
DILEFIECKW AEEKKAHALI REGYDSNFNG EAYASVCFQN ANLSVRLTDD 350
YMEAVRKNEN FQTRWITDKP TTEPPSYVAK ELLNKMAECA WHCGDPGVQY 400
DTTINKWHTC PNSGAINASN PCSEYMFLDD TACNLASINL MKFVQQDGSF 450
DHERFRAACR TFFIAQEILV DHASYPTEPI ARNSHKFRPL GLGYSNLGSV 500
IMTAGLPYDS DAARGMCGSL TALLHGEANR TSAELASVVG TFDGYVENEA 550
PMLRVMQMHR DACDQINDDG PAELKEAARE LWDGVLEIGE KYGFRNAQAT 600
VLAPTGTISF MMDCDTTGIE PDIALVKYKQ LAGGGMLKIV NQTVKLGLKT 650
LGYDADTIDE ILKYVDANDT IEGAPGLQDE HLAVFDCAFK PANGVRSIGW 700
RAHITMMAAA QPFLSGAISK TVNMPTDVTP QDIADAYFWG WELGLKAIAI 750
YRDGSKQSQP LNTKSDEQKA TDAAEAAKVE TVEKIVYKPR RERLPDTRQS 800
LTHKFSIAGH EGYLCVGLYP DGRPGEMFIT MAKEGSTIGG IMDSFGTALS 850
IAMQYGVPLE VIVNKFSHTR FEPMGHTSNK DIRIAKSVVD YIARWLGITF 900
MSGNDYSPSA EGAAKTGGNG PDLTTAPAGA TANNNSPVMA ELRADAGAAV 950
ALVERATLLA SLQNGVSNGS ATNGHSNGQS AGGSSDGAVA ERAVDGLGGQ 1000
ADQFSRFQTD APSCDNCGSI TVRNGNCYLC HNCGNSMGCS 1040
Length:1,040
Mass (Da):113,464
Last modified:October 1, 2003 - v1
Checksum:iD640951F588F5C03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294155 Genomic DNA. Translation: CAD77768.1.
RefSeqiNP_870691.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77768; CAD77768; RB12762.
GeneIDi1793559.
KEGGirba:RB12762.
PATRICi23253911. VBIRhoBal59814_6184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294155 Genomic DNA. Translation: CAD77768.1 .
RefSeqi NP_870691.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UI46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB12762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD77768 ; CAD77768 ; RB12762 .
GeneIDi 1793559.
KEGGi rba:RB12762.
PATRICi 23253911. VBIRhoBal59814_6184.

Phylogenomic databases

eggNOGi COG0209.
HOGENOMi HOG000021771.
KOi K00525.
OMAi TAFDIKF.
OrthoDBi EOG6H4K5F.

Family and domain databases

InterProi IPR013678. RNR_2_N.
IPR000788. RNR_lg_C.
IPR013344. RNR_NrdJ/NrdZ.
IPR024434. TSCPD_dom.
[Graphical view ]
Pfami PF08471. Ribonuc_red_2_N. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PF12637. TSCPD. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
TIGRFAMsi TIGR02504. NrdJ_Z. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiNRDJ_RHOBA
AccessioniPrimary (citable) accession number: Q7UI46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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