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Q7UHZ5

- DEF_RHOBA

UniProt

Q7UHZ5 - DEF_RHOBA

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Protein

Peptide deformylase

Gene

def

Organism
Rhodopirellula baltica (strain SH1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921IronUniRule annotation
Metal bindingi134 – 1341IronUniRule annotation
Active sitei135 – 1351UniRule annotation
Metal bindingi138 – 1381IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:RB12856
OrganismiRhodopirellula baltica (strain SH1)
Taxonomic identifieri243090 [NCBI]
Taxonomic lineageiBacteriaPlanctomycetesPlanctomycetiaPlanctomycetalesPlanctomycetaceaeRhodopirellula
ProteomesiUP000001025: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Peptide deformylasePRO_0000082828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243090.RB12856.

Structurei

3D structure databases

ProteinModelPortaliQ7UHZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
InParanoidiQ7UHZ5.
KOiK01462.
OMAiTIMYKEG.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UHZ5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLSIIHFPH PTLRHVSRPI VRVDAKLKSM ADEMLDLMYE FDGVGLAANQ
60 70 80 90 100
VDLPIRMFVA NPTGKRDEGE SWVILNPEID RPKGNDTAQE GCLSVPGLYG
110 120 130 140 150
QVKRPKTVRL RGFDLQGNEI NQVLDGFMAR VVQHEVDHLD GIMFFDRIGE
160 170 180 190 200
EGLRDLEGHL EEFKTDYESK QGTGSIADEA TLAQQRAEWE AMYTGGTTSN

G
Length:201
Mass (Da):22,469
Last modified:October 1, 2003 - v1
Checksum:i73DBBB623EBDF927
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294155 Genomic DNA. Translation: CAD77822.1.
RefSeqiNP_870745.1. NC_005027.1.

Genome annotation databases

EnsemblBacteriaiCAD77822; CAD77822; RB12856.
GeneIDi1793749.
KEGGirba:RB12856.
PATRICi23253999. VBIRhoBal59814_6228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX294155 Genomic DNA. Translation: CAD77822.1 .
RefSeqi NP_870745.1. NC_005027.1.

3D structure databases

ProteinModelPortali Q7UHZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243090.RB12856.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD77822 ; CAD77822 ; RB12856 .
GeneIDi 1793749.
KEGGi rba:RB12856.
PATRICi 23253999. VBIRhoBal59814_6228.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
InParanoidi Q7UHZ5.
KOi K01462.
OMAi TIMYKEG.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH1.

Entry informationi

Entry nameiDEF_RHOBA
AccessioniPrimary (citable) accession number: Q7UHZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3