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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Sitei174Important for catalytic activityUniRule annotation1
Active sitei176Proton donor/acceptorUniRule annotation1
Active sitei248NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:SF1111, S1191
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107991 – 341Beta-hexosaminidaseAdd BLAST341

Structurei

3D structure databases

ProteinModelPortaliQ7UCW4
SMRiQ7UCW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 164Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA Bacteria
COG1472 LUCA
HOGENOMiHOG000248526
KOiK01207
OMAiHKETPRD

Family and domain databases

Gene3Di3.20.20.300, 1 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR019800 Glyco_hydro_3_AS
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7UCW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVMLDVEG YELDAEEREI LAHPLVGGLI LFTRNYHDPA QLRELVRQIR
60 70 80 90 100
AASRNHLVVA VDQEGGRVQR FREGFTRLPA AQSFAALLGM EEGGKLAQEA
110 120 130 140 150
GWLMASEMIA MDIDISFAPV LDVGHISAAI GERSYHADPQ KALAIASRFI
160 170 180 190 200
DGMHEAGMKT TGKHFPGHGA VTADSHKETP CDPRPQAEIR AKDMSVFSSL
210 220 230 240 250
IRENKLDAIM PAHVIYSDVD PRPASGSPYW LKTVLRQELG FDGVIFSDDL
260 270 280 290 300
SMEGAAIMGS YAERGQASLD AGCDMILVCN NRKGAVSVLD NLSPIKAERV
310 320 330 340
TRLYHKGSFS RQELMDSARW KAISTRLNQL HERWQEEKAG H
Length:341
Mass (Da):37,602
Last modified:May 24, 2004 - v2
Checksum:i3233785CE886F9ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014073 Genomic DNA Translation: AAP16617.1
AE005674 Genomic DNA Translation: AAN42729.1
RefSeqiNP_707022.1, NC_004337.2
WP_000529300.1, NZ_MSKF02000083.1

Genome annotation databases

EnsemblBacteriaiAAN42729; AAN42729; SF1111
AAP16617; AAP16617; S1191
GeneIDi1024077
KEGGisfl:SF1111
sft:NCTC1_01165
sfx:S1191
PATRICifig|198214.7.peg.1301

Similar proteinsi

Entry informationi

Entry nameiNAGZ_SHIFL
AccessioniPrimary (citable) accession number: Q7UCW4
Secondary accession number(s): Q83LH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health