Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADPH-dependent FMN reductase ArsH

Gene

arsH

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has NADPH-dependent FMN reductase activity and very low azoreductase activity. No activity with NADH.1 Publication

Cofactori

FMN1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508FMNBy similarity

GO - Molecular functioni

  • azobenzene reductase activity Source: UniProtKB
  • FMN binding Source: UniProtKB
  • FMN reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB
  • protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent FMN reductase ArsHCurated (EC:1.-.-.-1 Publication)
Alternative name(s):
Arsenical resistance operon protein ArsHCuratedImported
Gene namesi
Name:arsH1 PublicationImported
Ordered Locus Names:S2709Imported
ORF Names:SF2457T_0606Imported
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255NADPH-dependent FMN reductase ArsHPRO_0000432221Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1
255
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni17 – 193Combined sources
Turni24 – 285Combined sources
Beta strandi36 – 427Combined sources
Beta strandi45 – 473Combined sources
Helixi49 – 6315Combined sources
Beta strandi67 – 715Combined sources
Turni79 – 813Combined sources
Helixi83 – 853Combined sources
Helixi88 – 9912Combined sources
Beta strandi101 – 11010Combined sources
Helixi116 – 1249Combined sources
Beta strandi139 – 1457Combined sources
Beta strandi147 – 1493Combined sources
Helixi153 – 16412Combined sources
Beta strandi174 – 1763Combined sources
Helixi179 – 1813Combined sources
Helixi193 – 21220Combined sources
Helixi213 – 2153Combined sources
Helixi216 – 2194Combined sources
Helixi223 – 2297Combined sources
Helixi235 – 2384Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FZVX-ray1.70A/B/C/D1-255[»]
ProteinModelPortaliQ7UC03.
SMRiQ7UC03. Positions 1-246.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7UC03.

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsH family.Curated

Phylogenomic databases

HOGENOMiHOG000112414.
KOiK11811.
OMAiNLSEAHA.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR014063. Arsenate-R_ArsH.
IPR029039. Flavoprotein-like_dom.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR02690. resist_ArsH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7UC03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRHLSDPD SLPALDKSFA IERPALGLAP DAPPVRILLL YGSLRARSFS
60 70 80 90 100
RLAVEEAARL LQFFGAETRI FDPSDLPLPD QVQSDDHPAV KELRALSEWS
110 120 130 140 150
EGQVWCSPER HGQITSVMKA QIDHLPLEMA GIRPTQGRTL AVMQVSGGSQ
160 170 180 190 200
SFNAVNTLRL LGRWMRMFTI PNQSSIAKAF QEFDAAGRMK PSPYYDRIAD
210 220 230 240 250
VMEELVRFTA LVRPHREALT DRYSERKAAG HVIDEATDLS SIAIAPQPLP

ESETS
Length:255
Mass (Da):28,400
Last modified:October 1, 2003 - v1
Checksum:i80740B0559A33296
GO

Sequence cautioni

The sequence EFS15380 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014073 Genomic DNA. Translation: AAP17869.1.
ADUV01000006 Genomic DNA. Translation: EFS15380.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAP17869; AAP17869; S2709.
EFS15380; EFS15380; SF2457T_0606.
KEGGisfx:S2709.
PATRICi18707056. VBIShiFle31049_2996.
51929987. VBIShiFle203745_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014073 Genomic DNA. Translation: AAP17869.1.
ADUV01000006 Genomic DNA. Translation: EFS15380.1. Different initiation.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FZVX-ray1.70A/B/C/D1-255[»]
ProteinModelPortaliQ7UC03.
SMRiQ7UC03. Positions 1-246.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP17869; AAP17869; S2709.
EFS15380; EFS15380; SF2457T_0606.
KEGGisfx:S2709.
PATRICi18707056. VBIShiFle31049_2996.
51929987. VBIShiFle203745_0575.

Phylogenomic databases

HOGENOMiHOG000112414.
KOiK11811.
OMAiNLSEAHA.

Miscellaneous databases

EvolutionaryTraceiQ7UC03.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR014063. Arsenate-R_ArsH.
IPR029039. Flavoprotein-like_dom.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR02690. resist_ArsH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARREH_SHIFL
AccessioniPrimary (citable) accession number: Q7UC03
Secondary accession number(s): E3XY12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.