Q7U9S3 (KDSA_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	SYNW0180

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187167

Sequences

	Sequence		Length	Mass (Da)
	Q7U9S3 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 98559C4D7E5C898C	FASTA	283	30,688
	10 20 30 40 50 60 MTARQIQLGD ITFANDRPFA LLGGVNVLED LDFALRCAGH YKQVCERLGI PLVFKASYDK 70 80 90 100 110 120 ANRSSIHSFR GPGLEAGLQI LQAVKDTLGI PVITDVHSPE EAKAAAKVAD IIQLPAFLAR 130 140 150 160 170 180 QTDLVRAMAE TGAVINIKKP QFLSPEQIRN IVDKFRECGN EQLLICERGT NFGYDNLVVD 190 200 210 220 230 240 MLGFGVMKRT CDDLPLIFDV THALQCRDPG GAASGGRRSQ VVDLAKAGMA VGLAGLFLEA 250 260 270 280 HPDPNQARCD GPSALPLDQL EPFLTQVKAI DDLVKSQPMI NIN

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569689 Genomic DNA. Translation: CAE06695.1.
RefSeq	NP_896275.1. NC_005070.1.
3D structure databases
ProteinModelPortal	Q7U9S3.
SMR	Q7U9S3. Positions 1-275.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7U9S3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1732414.
GenomeReviews	Gene locus SYNW0180 in contig BX548020_GR.
KEGG	syw:SYNW0180.
PATRIC	23831735. VBISynSp27240_0182.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2877.
HOGENOM	HBG575990.
OMA	QLILCDR.
PhylomeDB	Q7U9S3.
ProtClustDB	PRK05198.
Enzyme and pathway databases
BioCyc	SSP84588:SYNW0180OR2312-MONOMER.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01627.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_SYNPX

Accession

Primary (citable) accession number: Q7U9S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program