Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7U9J7

- GLYA_SYNPX

UniProt

Q7U9J7 - GLYA_SYNPX

Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401Pyridoxal phosphateUniRule annotation
    Binding sitei60 – 601Pyridoxal phosphateUniRule annotation
    Binding sitei62 – 621SubstrateUniRule annotation
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei70 – 701Pyridoxal phosphateUniRule annotation
    Binding sitei126 – 1261Substrate; via carbonyl oxygenUniRule annotation
    Binding sitei181 – 1811Pyridoxal phosphateUniRule annotation
    Binding sitei209 – 2091Pyridoxal phosphateUniRule annotation
    Binding sitei234 – 2341Pyridoxal phosphateUniRule annotation
    Binding sitei241 – 2411Pyridoxal phosphateUniRule annotation
    Binding sitei267 – 2671Pyridoxal phosphate; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei367 – 3671Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, One-carbon metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00193.
    UPA00288; UER01023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.1UniRule annotation)
    Short name:
    SHMTUniRule annotation
    Short name:
    Serine methylaseUniRule annotation
    Gene namesi
    Name:glyAUniRule annotation
    Ordered Locus Names:SYNW0259
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Serine hydroxymethyltransferasePRO_0000113682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei235 – 2351N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi84588.SYNW0259.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U9J7.
    SMRiQ7U9J7. Positions 11-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Substrate bindingUniRule annotation
    Regioni359 – 3613Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SHMT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0112.
    HOGENOMiHOG000239404.
    KOiK00600.
    OMAiHLMLVDV.
    OrthoDBiEOG6Z0QB2.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00051. SHMT.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view]
    PANTHERiPTHR11680. PTHR11680. 1 hit.
    PfamiPF00464. SHMT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000412. SHMT. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00096. SHMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7U9J7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSTASSIN KGLAAADPAI AALIEKEQQR QETHLELIAS ENFASRAVMD    50
    AQGSVLTNKY AEGLPSKRYY GGCEHVDAIE ELAIERAKEL FGAAWANVQP 100
    HSGAQANFAV FLALLQPGDT IMGLDLSHGG HLTHGSPVNV SGKWFNVVQY 150
    GVDRETQRLD MEAIRQLALE HKPKLIVCGF SAYPRTIDFA AFRAIADEVG 200
    AFLLADMAHI AGLVAAGVHP SPVPHCDVVT TTTHKTLRGP RGGLILCRDA 250
    DFAKKFDKAV FPGSQGGPLE HVIAAKAVAF GEALQPAFKT YSQHVVANAA 300
    ALAERLIARG IDVVSGGTDN HVVLLDLRSV GMTGKVADLL VSDVHITANK 350
    NTVPFDPESP FVTSGLRLGT AALTTRGFDA GAFREVADVI ADRLLNPEDD 400
    AVQQQCLRRV EALCQRFPLY AAARQPALA 429
    Length:429
    Mass (Da):45,756
    Last modified:October 1, 2003 - v1
    Checksum:i8177A683A10E3D6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569689 Genomic DNA. Translation: CAE06774.1.
    RefSeqiNP_896354.1. NC_005070.1.
    WP_011127135.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE06774; CAE06774; SYNW0259.
    GeneIDi1730097.
    KEGGisyw:SYNW0259.
    PATRICi23831899. VBISynSp27240_0262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569689 Genomic DNA. Translation: CAE06774.1 .
    RefSeqi NP_896354.1. NC_005070.1.
    WP_011127135.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U9J7.
    SMRi Q7U9J7. Positions 11-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE06774 ; CAE06774 ; SYNW0259 .
    GeneIDi 1730097.
    KEGGi syw:SYNW0259.
    PATRICi 23831899. VBISynSp27240_0262.

    Phylogenomic databases

    eggNOGi COG0112.
    HOGENOMi HOG000239404.
    KOi K00600.
    OMAi HLMLVDV.
    OrthoDBi EOG6Z0QB2.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    UPA00288 ; UER01023 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00051. SHMT.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view ]
    PANTHERi PTHR11680. PTHR11680. 1 hit.
    Pfami PF00464. SHMT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000412. SHMT. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00096. SHMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiGLYA_SYNPX
    AccessioniPrimary (citable) accession number: Q7U9J7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3