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Q7U9J7

- GLYA_SYNPX

UniProt

Q7U9J7 - GLYA_SYNPX

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Protein
Serine hydroxymethyltransferase
Gene
glyA, SYNW0259
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Pyridoxal phosphate By similarity
Binding sitei60 – 601Pyridoxal phosphate By similarity
Binding sitei62 – 621Substrate By similarity
Binding sitei69 – 691Substrate By similarity
Binding sitei70 – 701Pyridoxal phosphate By similarity
Binding sitei126 – 1261Substrate; via carbonyl oxygen By similarity
Binding sitei181 – 1811Pyridoxal phosphate By similarity
Binding sitei209 – 2091Pyridoxal phosphate By similarity
Binding sitei234 – 2341Pyridoxal phosphate By similarity
Binding sitei241 – 2411Pyridoxal phosphate By similarity
Binding sitei267 – 2671Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei367 – 3671Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00193.
UPA00288; UER01023.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferase (EC:2.1.2.1)
Short name:
SHMT
Short name:
Serine methylase
Gene namesi
Name:glyA
Ordered Locus Names:SYNW0259
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Serine hydroxymethyltransferaseUniRule annotation
PRO_0000113682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi84588.SYNW0259.

Structurei

3D structure databases

ProteinModelPortaliQ7U9J7.
SMRiQ7U9J7. Positions 11-413.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1323Substrate binding By similarity
Regioni359 – 3613Substrate binding By similarity

Sequence similaritiesi

Belongs to the SHMT family.

Phylogenomic databases

eggNOGiCOG0112.
HOGENOMiHOG000239404.
KOiK00600.
OMAiHLMLVDV.
OrthoDBiEOG6Z0QB2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U9J7-1 [UniParc]FASTAAdd to Basket

« Hide

MSDSTASSIN KGLAAADPAI AALIEKEQQR QETHLELIAS ENFASRAVMD    50
AQGSVLTNKY AEGLPSKRYY GGCEHVDAIE ELAIERAKEL FGAAWANVQP 100
HSGAQANFAV FLALLQPGDT IMGLDLSHGG HLTHGSPVNV SGKWFNVVQY 150
GVDRETQRLD MEAIRQLALE HKPKLIVCGF SAYPRTIDFA AFRAIADEVG 200
AFLLADMAHI AGLVAAGVHP SPVPHCDVVT TTTHKTLRGP RGGLILCRDA 250
DFAKKFDKAV FPGSQGGPLE HVIAAKAVAF GEALQPAFKT YSQHVVANAA 300
ALAERLIARG IDVVSGGTDN HVVLLDLRSV GMTGKVADLL VSDVHITANK 350
NTVPFDPESP FVTSGLRLGT AALTTRGFDA GAFREVADVI ADRLLNPEDD 400
AVQQQCLRRV EALCQRFPLY AAARQPALA 429
Length:429
Mass (Da):45,756
Last modified:October 1, 2003 - v1
Checksum:i8177A683A10E3D6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569689 Genomic DNA. Translation: CAE06774.1.
RefSeqiNP_896354.1. NC_005070.1.
WP_011127135.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE06774; CAE06774; SYNW0259.
GeneIDi1730097.
KEGGisyw:SYNW0259.
PATRICi23831899. VBISynSp27240_0262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569689 Genomic DNA. Translation: CAE06774.1 .
RefSeqi NP_896354.1. NC_005070.1.
WP_011127135.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U9J7.
SMRi Q7U9J7. Positions 11-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW0259.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE06774 ; CAE06774 ; SYNW0259 .
GeneIDi 1730097.
KEGGi syw:SYNW0259.
PATRICi 23831899. VBISynSp27240_0262.

Phylogenomic databases

eggNOGi COG0112.
HOGENOMi HOG000239404.
KOi K00600.
OMAi HLMLVDV.
OrthoDBi EOG6Z0QB2.

Enzyme and pathway databases

UniPathwayi UPA00193 .
UPA00288 ; UER01023 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00051. SHMT.
InterProi IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view ]
PANTHERi PTHR11680. PTHR11680. 1 hit.
Pfami PF00464. SHMT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000412. SHMT. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00096. SHMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiGLYA_SYNPX
AccessioniPrimary (citable) accession number: Q7U9J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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