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Q7U9D4

- DEF_SYNPX

UniProt

Q7U9D4 - DEF_SYNPX

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Protein
Peptide deformylase
Gene
def, SYNW0324
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211Iron By similarity
Metal bindingi163 – 1631Iron By similarity
Active sitei164 – 1641 By similarity
Metal bindingi167 – 1671Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:SYNW0324
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Peptide deformylaseUniRule annotation
PRO_0000082864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW0324.

Structurei

3D structure databases

ProteinModelPortaliQ7U9D4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiMEMVFYP.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U9D4-1 [UniParc]FASTAAdd to Basket

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MAGSFAQLAR AAEQSRDTML VPKTALETPP LEIHTLGAEV LRQSARRIGK    50
VTEQTRELAR DMLRSMYTAK GIGLAAPQVG IHQQLLVIDL DLENAATPPL 100
VLINPEISAA SASIDTYEEG CLSIPGVYLD VVRPTAIELS FRDEMGRPRK 150
MKADGLMARC IQHEMDHLNG VLFVDRVTDE AGLQKELKDH GFQRQHVQSV 200
S 201
Length:201
Mass (Da):22,123
Last modified:October 1, 2003 - v1
Checksum:i96ED79F01249FA48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569689 Genomic DNA. Translation: CAE06839.1.
RefSeqiNP_896419.1. NC_005070.1.
WP_011127198.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE06839; CAE06839; SYNW0324.
GeneIDi1730104.
KEGGisyw:SYNW0324.
PATRICi23832037. VBISynSp27240_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569689 Genomic DNA. Translation: CAE06839.1 .
RefSeqi NP_896419.1. NC_005070.1.
WP_011127198.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U9D4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW0324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE06839 ; CAE06839 ; SYNW0324 .
GeneIDi 1730104.
KEGGi syw:SYNW0324.
PATRICi 23832037. VBISynSp27240_0329.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi MEMVFYP.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiDEF_SYNPX
AccessioniPrimary (citable) accession number: Q7U9D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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