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Q7U8K7

- HISX_SYNPX

UniProt

Q7U8K7 - HISX_SYNPX

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371NADUniRule annotation
Binding sitei199 – 1991NADUniRule annotation
Binding sitei222 – 2221NADUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation
Metal bindingi267 – 2671ZincUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Metal bindingi270 – 2701ZincUniRule annotation
Binding sitei270 – 2701SubstrateUniRule annotation
Active sitei335 – 3351Proton acceptorUniRule annotation
Active sitei336 – 3361Proton acceptorUniRule annotation
Binding sitei336 – 3361SubstrateUniRule annotation
Metal bindingi369 – 3691ZincUniRule annotation
Binding sitei369 – 3691SubstrateUniRule annotation
Binding sitei423 – 4231SubstrateUniRule annotation
Metal bindingi428 – 4281ZincUniRule annotation
Binding sitei428 – 4281SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:SYNW0610
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Histidinol dehydrogenasePRO_0000135864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW0610.

Structurei

3D structure databases

ProteinModelPortaliQ7U8K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U8K7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESRSLAFP LRCVRDRQQA EAELQRLTRR TQTSQQKDVQ GRVDVILKAV
60 70 80 90 100
RERGDAAVCD FTERFDGFRP DPVAVPKHQL EQAWKALPEN LRDALELAHR
110 120 130 140 150
RISEFHQRQR PEDIRMEGAH GEQLGRRWRP VQRAGLYVPG GRAAYPSTVL
160 170 180 190 200
MNAVPARVAG VEQVVICSPA GSNGQVNPVV LAAAHLAGVH TVMRIGGAQA
210 220 230 240 250
IAAMAFGTES VPKVDVISGP GNIYVTLAKQ AVYGQVGIDS LAGPSEVLVI
260 270 280 290 300
ADQSAQPEQV AADLLAQAEH DPLASSVLIT TSHQLADGIS SAIAQQLEDH
310 320 330 340 350
PRREICEASL RDWGLVVVCD DLETCAQLSD SFAPEHLELL VERPEALADR
360 370 380 390 400
IQHAGAIFLG PWSPEAVGDY LAGPNHTLPT CAAARFSGAL SVETFMRHTS
410 420 430
MIQFNRAALD ATASAVCELA ESEGLHSHAE SVRKRLS
Length:437
Mass (Da):47,265
Last modified:October 1, 2003 - v1
Checksum:i65B60CDC936925E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569690 Genomic DNA. Translation: CAE07125.1.
RefSeqiNP_896703.1. NC_005070.1.
WP_011127477.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE07125; CAE07125; SYNW0610.
GeneIDi1732243.
KEGGisyw:SYNW0610.
PATRICi23832641. VBISynSp27240_0629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569690 Genomic DNA. Translation: CAE07125.1 .
RefSeqi NP_896703.1. NC_005070.1.
WP_011127477.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U8K7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW0610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE07125 ; CAE07125 ; SYNW0610 .
GeneIDi 1732243.
KEGGi syw:SYNW0610.
PATRICi 23832641. VBISynSp27240_0629.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiHISX_SYNPX
AccessioniPrimary (citable) accession number: Q7U8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3