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Q7U8K7

- HISX_SYNPX

UniProt

Q7U8K7 - HISX_SYNPX

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Protein

Histidinol dehydrogenase

Gene
hisD, SYNW0610
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371NAD By similarity
Binding sitei199 – 1991NAD By similarity
Binding sitei222 – 2221NAD By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Metal bindingi270 – 2701Zinc By similarity
Binding sitei270 – 2701Substrate By similarity
Active sitei335 – 3351Proton acceptor By similarity
Active sitei336 – 3361Proton acceptor By similarity
Binding sitei336 – 3361Substrate By similarity
Metal bindingi369 – 3691Zinc By similarity
Binding sitei369 – 3691Substrate By similarity
Binding sitei423 – 4231Substrate By similarity
Metal bindingi428 – 4281Zinc By similarity
Binding sitei428 – 4281Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:SYNW0610
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Histidinol dehydrogenaseUniRule annotationPRO_0000135864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW0610.

Structurei

3D structure databases

ProteinModelPortaliQ7U8K7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7U8K7-1 [UniParc]FASTAAdd to Basket

« Hide

MSESRSLAFP LRCVRDRQQA EAELQRLTRR TQTSQQKDVQ GRVDVILKAV    50
RERGDAAVCD FTERFDGFRP DPVAVPKHQL EQAWKALPEN LRDALELAHR 100
RISEFHQRQR PEDIRMEGAH GEQLGRRWRP VQRAGLYVPG GRAAYPSTVL 150
MNAVPARVAG VEQVVICSPA GSNGQVNPVV LAAAHLAGVH TVMRIGGAQA 200
IAAMAFGTES VPKVDVISGP GNIYVTLAKQ AVYGQVGIDS LAGPSEVLVI 250
ADQSAQPEQV AADLLAQAEH DPLASSVLIT TSHQLADGIS SAIAQQLEDH 300
PRREICEASL RDWGLVVVCD DLETCAQLSD SFAPEHLELL VERPEALADR 350
IQHAGAIFLG PWSPEAVGDY LAGPNHTLPT CAAARFSGAL SVETFMRHTS 400
MIQFNRAALD ATASAVCELA ESEGLHSHAE SVRKRLS 437
Length:437
Mass (Da):47,265
Last modified:October 1, 2003 - v1
Checksum:i65B60CDC936925E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569690 Genomic DNA. Translation: CAE07125.1.
RefSeqiNP_896703.1. NC_005070.1.
WP_011127477.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE07125; CAE07125; SYNW0610.
GeneIDi1732243.
KEGGisyw:SYNW0610.
PATRICi23832641. VBISynSp27240_0629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX569690 Genomic DNA. Translation: CAE07125.1 .
RefSeqi NP_896703.1. NC_005070.1.
WP_011127477.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U8K7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW0610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE07125 ; CAE07125 ; SYNW0610 .
GeneIDi 1732243.
KEGGi syw:SYNW0610.
PATRICi 23832641. VBISynSp27240_0629.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiHISX_SYNPX
AccessioniPrimary (citable) accession number: Q7U8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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