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Q7U8K7

- HISX_SYNPX

UniProt

Q7U8K7 - HISX_SYNPX

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371NADUniRule annotation
    Binding sitei199 – 1991NADUniRule annotation
    Binding sitei222 – 2221NADUniRule annotation
    Binding sitei245 – 2451SubstrateUniRule annotation
    Metal bindingi267 – 2671ZincUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Metal bindingi270 – 2701ZincUniRule annotation
    Binding sitei270 – 2701SubstrateUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Active sitei336 – 3361Proton acceptorUniRule annotation
    Binding sitei336 – 3361SubstrateUniRule annotation
    Metal bindingi369 – 3691ZincUniRule annotation
    Binding sitei369 – 3691SubstrateUniRule annotation
    Binding sitei423 – 4231SubstrateUniRule annotation
    Metal bindingi428 – 4281ZincUniRule annotation
    Binding sitei428 – 4281SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:SYNW0610
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Histidinol dehydrogenasePRO_0000135864Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW0610.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U8K7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7U8K7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESRSLAFP LRCVRDRQQA EAELQRLTRR TQTSQQKDVQ GRVDVILKAV    50
    RERGDAAVCD FTERFDGFRP DPVAVPKHQL EQAWKALPEN LRDALELAHR 100
    RISEFHQRQR PEDIRMEGAH GEQLGRRWRP VQRAGLYVPG GRAAYPSTVL 150
    MNAVPARVAG VEQVVICSPA GSNGQVNPVV LAAAHLAGVH TVMRIGGAQA 200
    IAAMAFGTES VPKVDVISGP GNIYVTLAKQ AVYGQVGIDS LAGPSEVLVI 250
    ADQSAQPEQV AADLLAQAEH DPLASSVLIT TSHQLADGIS SAIAQQLEDH 300
    PRREICEASL RDWGLVVVCD DLETCAQLSD SFAPEHLELL VERPEALADR 350
    IQHAGAIFLG PWSPEAVGDY LAGPNHTLPT CAAARFSGAL SVETFMRHTS 400
    MIQFNRAALD ATASAVCELA ESEGLHSHAE SVRKRLS 437
    Length:437
    Mass (Da):47,265
    Last modified:October 1, 2003 - v1
    Checksum:i65B60CDC936925E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569690 Genomic DNA. Translation: CAE07125.1.
    RefSeqiNP_896703.1. NC_005070.1.
    WP_011127477.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE07125; CAE07125; SYNW0610.
    GeneIDi1732243.
    KEGGisyw:SYNW0610.
    PATRICi23832641. VBISynSp27240_0629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569690 Genomic DNA. Translation: CAE07125.1 .
    RefSeqi NP_896703.1. NC_005070.1.
    WP_011127477.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U8K7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE07125 ; CAE07125 ; SYNW0610 .
    GeneIDi 1732243.
    KEGGi syw:SYNW0610.
    PATRICi 23832641. VBISynSp27240_0629.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiHISX_SYNPX
    AccessioniPrimary (citable) accession number: Q7U8K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3