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Q7U851

- HIS4_SYNPX

UniProt

Q7U851 - HIS4_SYNPX

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81Proton acceptorUniRule annotation
    Active sitei129 – 1291Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:hisAUniRule annotation
    Ordered Locus Names:SYNW0773
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2552551-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000142065Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW0773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U851.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    OMAiQRDYGSD.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U851-1 [UniParc]FASTAAdd to Basket

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    MEILPAIDLL DGACVRLHKG DYEQVTRFSD DPVAQALSWQ QQGATRLHLV    50
    DLDGAKRGEP VNDSAVQAIT SALDIPVQLG GGVRSLERAE QLLACGLDRV 100
    ILGTVAIEQP DLVRSLAERY PGRIVVGIDA KDGRVATRGW IEQSDVLATD 150
    LARTFSSSGI AAIITTDIAT DGTLAGPNLE ALRTMAASSS VPVIASGGIG 200
    CMADLLSLLP LEPLGVSGVI VGRALYDGRV DLAEAVRALA EPRLQDITAV 250
    AADLA 255
    Length:255
    Mass (Da):26,637
    Last modified:October 1, 2003 - v1
    Checksum:iDC9F7596039E3452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07288.1.
    RefSeqiNP_896866.1. NC_005070.1.
    WP_011127638.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE07288; CAE07288; SYNW0773.
    GeneIDi1732108.
    KEGGisyw:SYNW0773.
    PATRICi23832987. VBISynSp27240_0801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07288.1 .
    RefSeqi NP_896866.1. NC_005070.1.
    WP_011127638.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U851.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE07288 ; CAE07288 ; SYNW0773 .
    GeneIDi 1732108.
    KEGGi syw:SYNW0773.
    PATRICi 23832987. VBISynSp27240_0801.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    OMAi QRDYGSD.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiHIS4_SYNPX
    AccessioniPrimary (citable) accession number: Q7U851
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3