Q7U807 (DAPB_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	SYNW0819

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141500

Sequences

	Sequence		Length	Mass (Da)
	Q7U807 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 170D837503FE75DF	FASTA	277	29,102
	10 20 30 40 50 60 MTPSIPVVVA GALGRMGAEV IKAVVGSADC MLVGAIDNTP GKEGSDIGLE LGLGELEVAV 70 80 90 100 110 120 TADFEGCLCA VSQSVRDAEA GAVLVDFTHP SVVYEHTRAA IAYGVHPVIG TTGLSPEQLS 130 140 150 160 170 180 DLCQFAAKAS IGGAVIPNFS VGMVLLQQAA AAAARFYDHA ELTELHHNCK ADAPSGTCIK 190 200 210 220 230 240 TAELMEELGK SFNPAEVDEH ESLAGSRGGR RESGLRLHSL RLPGLVAHQE VMFGAPGETY 250 260 270 TLRHDTIDRS AYMPGVLLTV RKVRSLQTLV YGLERLI

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed: 12917641] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569691 Genomic DNA. Translation: CAE07334.1.
RefSeq	NP_896912.1. NC_005070.1.
3D structure databases
ProteinModelPortal	Q7U807.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7U807.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1732521.
GenomeReviews	Gene locus SYNW0819 in contig BX548020_GR.
KEGG	syw:SYNW0819.
PATRIC	23833085. VBISynSp27240_0850.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	PESENTH.
PhylomeDB	Q7U807.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	SSP84588:SYNW0819OR1878-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_SYNPX

Accession

Primary (citable) accession number: Q7U807

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program