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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Metal cation 1UniRule annotation1
Metal bindingi10Metal cation 1UniRule annotation1
Binding sitei10cAMPUniRule annotation1
Metal bindingi48Metal cation 1UniRule annotation1
Metal bindingi48Metal cation 2UniRule annotation1
Binding sitei48cAMPUniRule annotation1
Metal bindingi79Metal cation 2UniRule annotation1
Metal bindingi150Metal cation 2UniRule annotation1
Metal bindingi189Metal cation 2UniRule annotation1
Metal bindingi191Metal cation 1UniRule annotation1
Binding sitei191cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 80cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:icc
Ordered Locus Names:SYNW0868
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001422 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133811 – 2533',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST253

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW0868.

Structurei

3D structure databases

ProteinModelPortaliQ7U7W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238351.
KOiK03651.
OMAiFGHIHQH.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U7W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILQLSDPH LVAADAALVR ERPAMTLLDR ALLEGQRSHP DLVLISGDLC
60 70 80 90 100
QDESWGGYVR LGRLLDRHVN VPVGLLPGNH DDPLLLKAVL GRRFCTAPAE
110 120 130 140 150
LIVQGTRLVL LNSHRSGCSA GWLGPHQLQW LQERLADPLR RDLPLVVALH
160 170 180 190 200
HPPVAIGHPV MDTMNLSDHH QLAAILQPHA ALRAVVFGHI HQHWHGTWPQ
210 220 230 240 250
RPDVPLLGCP STLRSFQCVQ PCPLGRAEDP GGRLLEIHND GSLSHQVLRW

SPC
Length:253
Mass (Da):27,994
Last modified:October 1, 2003 - v1
Checksum:i9369C1267CB53C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569691 Genomic DNA. Translation: CAE07383.1.
RefSeqiWP_011127733.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE07383; CAE07383; SYNW0868.
KEGGisyw:SYNW0868.
PATRICi23833193. VBISynSp27240_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569691 Genomic DNA. Translation: CAE07383.1.
RefSeqiWP_011127733.1. NC_005070.1.

3D structure databases

ProteinModelPortaliQ7U7W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi84588.SYNW0868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE07383; CAE07383; SYNW0868.
KEGGisyw:SYNW0868.
PATRICi23833193. VBISynSp27240_0903.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000238351.
KOiK03651.
OMAiFGHIHQH.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_SYNPX
AccessioniPrimary (citable) accession number: Q7U7W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.