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Q7U7W2

- CPDA_SYNPX

UniProt

Q7U7W2 - CPDA_SYNPX

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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1UniRule annotation
Metal bindingi10 – 101Metal cation 1UniRule annotation
Binding sitei10 – 101cAMPUniRule annotation
Metal bindingi48 – 481Metal cation 1UniRule annotation
Metal bindingi48 – 481Metal cation 2UniRule annotation
Binding sitei48 – 481cAMPUniRule annotation
Metal bindingi79 – 791Metal cation 2UniRule annotation
Metal bindingi150 – 1501Metal cation 2UniRule annotation
Metal bindingi189 – 1891Metal cation 2UniRule annotation
Metal bindingi191 – 1911Metal cation 1UniRule annotation
Binding sitei191 – 1911cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Synonyms:icc
Ordered Locus Names:SYNW0868
OrganismiSynechococcus sp. (strain WH8102)
Taxonomic identifieri84588 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001422: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2532533',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi84588.SYNW0868.

Structurei

3D structure databases

ProteinModelPortaliQ7U7W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiLMCDSTI.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7U7W2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRILQLSDPH LVAADAALVR ERPAMTLLDR ALLEGQRSHP DLVLISGDLC
60 70 80 90 100
QDESWGGYVR LGRLLDRHVN VPVGLLPGNH DDPLLLKAVL GRRFCTAPAE
110 120 130 140 150
LIVQGTRLVL LNSHRSGCSA GWLGPHQLQW LQERLADPLR RDLPLVVALH
160 170 180 190 200
HPPVAIGHPV MDTMNLSDHH QLAAILQPHA ALRAVVFGHI HQHWHGTWPQ
210 220 230 240 250
RPDVPLLGCP STLRSFQCVQ PCPLGRAEDP GGRLLEIHND GSLSHQVLRW

SPC
Length:253
Mass (Da):27,994
Last modified:October 1, 2003 - v1
Checksum:i9369C1267CB53C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569691 Genomic DNA. Translation: CAE07383.1.
RefSeqiNP_896961.1. NC_005070.1.
WP_011127733.1. NC_005070.1.

Genome annotation databases

EnsemblBacteriaiCAE07383; CAE07383; SYNW0868.
GeneIDi1730957.
KEGGisyw:SYNW0868.
PATRICi23833193. VBISynSp27240_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX569691 Genomic DNA. Translation: CAE07383.1 .
RefSeqi NP_896961.1. NC_005070.1.
WP_011127733.1. NC_005070.1.

3D structure databases

ProteinModelPortali Q7U7W2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 84588.SYNW0868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE07383 ; CAE07383 ; SYNW0868 .
GeneIDi 1730957.
KEGGi syw:SYNW0868.
PATRICi 23833193. VBISynSp27240_0903.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000238351.
KOi K03651.
OMAi LMCDSTI.
OrthoDBi EOG6QG8GQ.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WH8102.

Entry informationi

Entry nameiCPDA_SYNPX
AccessioniPrimary (citable) accession number: Q7U7W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3