Q7U7W2 (CPDA_SYNPX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17

Gene names

Name:	cpdA
Synonyms:	icc
Ordered Locus Names:	SYNW0868

Organism

Synechococcus sp. (strain WH8102) [Complete proteome] [HAMAP]

Taxonomic identifier

84588 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905
Cofactor	Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905
Sequence similarities	Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
Ligand	Metal-binding Nucleotide-binding cAMP
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905		PRO_0000413381
Regions
	Nucleotide binding	79 – 80	2	cAMP By similarity
Sites
	Metal binding	8	1	Metal cation 1 By similarity
	Metal binding	10	1	Metal cation 1 By similarity
	Metal binding	48	1	Metal cation 1 By similarity
	Metal binding	48	1	Metal cation 2 By similarity
	Metal binding	79	1	Metal cation 2 By similarity
	Metal binding	150	1	Metal cation 2 By similarity
	Metal binding	189	1	Metal cation 2 By similarity
	Metal binding	191	1	Metal cation 1 By similarity
	Binding site	10	1	cAMP By similarity
	Binding site	48	1	cAMP By similarity
	Binding site	191	1	cAMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7U7W2 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9369C1267CB53C56	FASTA	253	27,994
	10 20 30 40 50 60 MRILQLSDPH LVAADAALVR ERPAMTLLDR ALLEGQRSHP DLVLISGDLC QDESWGGYVR 70 80 90 100 110 120 LGRLLDRHVN VPVGLLPGNH DDPLLLKAVL GRRFCTAPAE LIVQGTRLVL LNSHRSGCSA 130 140 150 160 170 180 GWLGPHQLQW LQERLADPLR RDLPLVVALH HPPVAIGHPV MDTMNLSDHH QLAAILQPHA 190 200 210 220 230 240 ALRAVVFGHI HQHWHGTWPQ RPDVPLLGCP STLRSFQCVQ PCPLGRAEDP GGRLLEIHND 250 GSLSHQVLRW SPC

References

[1]

"The genome of a motile marine Synechococcus." Palenik B., Brahamsha B., Larimer F.W., Land M.L., Hauser L., Chain P., Lamerdin J.E., Regala W., Allen E.E., McCarren J., Paulsen I.T., Dufresne A., Partensky F., Webb E.A., Waterbury J. Nature 424:1037-1042(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WH8102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX569691 Genomic DNA. Translation: CAE07383.1.
RefSeq	NP_896961.1. NC_005070.1.
3D structure databases
ProteinModelPortal	Q7U7W2.
ModBase	Search...
Protein-protein interaction databases
STRING	84588.SYNW0868.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE07383; CAE07383; SYNW0868.
GeneID	1730957.
KEGG	syw:SYNW0868.
PATRIC	23833193. VBISynSp27240_0903.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1409.
HOGENOM	HOG000238351.
KO	K03651.
OMA	HGTEAEY.
ProtClustDB	CLSK826164.
Family and domain databases
HAMAP	MF_00905. cAMP_phophodiest_CpdA.
InterPro	IPR026575. cAMP_Pdiest_CpdA. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CPDA_SYNPX

Accession

Primary (citable) accession number: Q7U7W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program