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Q7U7W2

- CPDA_SYNPX

UniProt

Q7U7W2 - CPDA_SYNPX

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Metal cation 1UniRule annotation
    Metal bindingi10 – 101Metal cation 1UniRule annotation
    Binding sitei10 – 101cAMPUniRule annotation
    Metal bindingi48 – 481Metal cation 1UniRule annotation
    Metal bindingi48 – 481Metal cation 2UniRule annotation
    Binding sitei48 – 481cAMPUniRule annotation
    Metal bindingi79 – 791Metal cation 2UniRule annotation
    Metal bindingi150 – 1501Metal cation 2UniRule annotation
    Metal bindingi189 – 1891Metal cation 2UniRule annotation
    Metal bindingi191 – 1911Metal cation 1UniRule annotation
    Binding sitei191 – 1911cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi79 – 802cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Synonyms:icc
    Ordered Locus Names:SYNW0868
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532533',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413381Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW0868.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U7W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238351.
    KOiK03651.
    OMAiLMCDSTI.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U7W2-1 [UniParc]FASTAAdd to Basket

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    MRILQLSDPH LVAADAALVR ERPAMTLLDR ALLEGQRSHP DLVLISGDLC    50
    QDESWGGYVR LGRLLDRHVN VPVGLLPGNH DDPLLLKAVL GRRFCTAPAE 100
    LIVQGTRLVL LNSHRSGCSA GWLGPHQLQW LQERLADPLR RDLPLVVALH 150
    HPPVAIGHPV MDTMNLSDHH QLAAILQPHA ALRAVVFGHI HQHWHGTWPQ 200
    RPDVPLLGCP STLRSFQCVQ PCPLGRAEDP GGRLLEIHND GSLSHQVLRW 250
    SPC 253
    Length:253
    Mass (Da):27,994
    Last modified:October 1, 2003 - v1
    Checksum:i9369C1267CB53C56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07383.1.
    RefSeqiNP_896961.1. NC_005070.1.
    WP_011127733.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE07383; CAE07383; SYNW0868.
    GeneIDi1730957.
    KEGGisyw:SYNW0868.
    PATRICi23833193. VBISynSp27240_0903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07383.1 .
    RefSeqi NP_896961.1. NC_005070.1.
    WP_011127733.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U7W2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE07383 ; CAE07383 ; SYNW0868 .
    GeneIDi 1730957.
    KEGGi syw:SYNW0868.
    PATRICi 23833193. VBISynSp27240_0903.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238351.
    KOi K03651.
    OMAi LMCDSTI.
    OrthoDBi EOG6QG8GQ.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiCPDA_SYNPX
    AccessioniPrimary (citable) accession number: Q7U7W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3