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Q7U7W2

- CPDA_SYNPX

UniProt

Q7U7W2 - CPDA_SYNPX

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, icc, SYNW0868
Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Metal cation 1 By similarity
Metal bindingi10 – 101Metal cation 1 By similarity
Binding sitei10 – 101cAMP By similarity
Metal bindingi48 – 481Metal cation 1 By similarity
Metal bindingi48 – 481Metal cation 2 By similarity
Binding sitei48 – 481cAMP By similarity
Metal bindingi79 – 791Metal cation 2 By similarity
Metal bindingi150 – 1501Metal cation 2 By similarity
Metal bindingi189 – 1891Metal cation 2 By similarity
Metal bindingi191 – 1911Metal cation 1 By similarity
Binding sitei191 – 1911cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
    Short name:
    3',5'-cyclic AMP phosphodiesterase
    Short name:
    cAMP phosphodiesterase
    Gene namesi
    Name:cpdA
    Synonyms:icc
    Ordered Locus Names:SYNW0868
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532533',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
    PRO_0000413381Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW0868.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U7W2.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238351.
    KOiK03651.
    OMAiLMCDSTI.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U7W2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILQLSDPH LVAADAALVR ERPAMTLLDR ALLEGQRSHP DLVLISGDLC    50
    QDESWGGYVR LGRLLDRHVN VPVGLLPGNH DDPLLLKAVL GRRFCTAPAE 100
    LIVQGTRLVL LNSHRSGCSA GWLGPHQLQW LQERLADPLR RDLPLVVALH 150
    HPPVAIGHPV MDTMNLSDHH QLAAILQPHA ALRAVVFGHI HQHWHGTWPQ 200
    RPDVPLLGCP STLRSFQCVQ PCPLGRAEDP GGRLLEIHND GSLSHQVLRW 250
    SPC 253
    Length:253
    Mass (Da):27,994
    Last modified:October 1, 2003 - v1
    Checksum:i9369C1267CB53C56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07383.1.
    RefSeqiNP_896961.1. NC_005070.1.
    WP_011127733.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE07383; CAE07383; SYNW0868.
    GeneIDi1730957.
    KEGGisyw:SYNW0868.
    PATRICi23833193. VBISynSp27240_0903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07383.1 .
    RefSeqi NP_896961.1. NC_005070.1.
    WP_011127733.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U7W2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE07383 ; CAE07383 ; SYNW0868 .
    GeneIDi 1730957.
    KEGGi syw:SYNW0868.
    PATRICi 23833193. VBISynSp27240_0903.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238351.
    KOi K03651.
    OMAi LMCDSTI.
    OrthoDBi EOG6QG8GQ.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiCPDA_SYNPX
    AccessioniPrimary (citable) accession number: Q7U7W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 1, 2003
    Last modified: September 3, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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