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Q7U7Q2

- LIPA2_SYNPX

UniProt

Q7U7Q2 - LIPA2_SYNPX

Protein

Lipoyl synthase 2

Gene

lipA2

Organism
Synechococcus sp. (strain WH8102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.UniRule annotation

    Catalytic activityi

    Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi43 – 431Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi48 – 481Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi54 – 541Iron-sulfur 1 (4Fe-4S)UniRule annotation
    Metal bindingi69 – 691Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi73 – 731Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi76 – 761Iron-sulfur 2 (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. lipoate synthase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein lipoylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00538; UER00593.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoyl synthase 2UniRule annotation (EC:2.8.1.8UniRule annotation)
    Alternative name(s):
    Lip-syn 2UniRule annotation
    Lipoate synthase 2UniRule annotation
    Lipoic acid synthase 2UniRule annotation
    Sulfur insertion protein lipA2
    Gene namesi
    Name:lipA2UniRule annotation
    Synonyms:lipA
    Ordered Locus Names:SYNW0929
    OrganismiSynechococcus sp. (strain WH8102)
    Taxonomic identifieri84588 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001422: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Lipoyl synthase 2PRO_0000102370Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi84588.SYNW0929.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7U7Q2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the radical SAM superfamily. Lipoyl synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0320.
    HOGENOMiHOG000235997.
    KOiK03644.
    OMAiEWLRRPI.
    OrthoDBiEOG6038ZS.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00206. Lipoyl_synth.
    InterProiIPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view]
    PANTHERiPTHR10949. PTHR10949. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00510. lipA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7U7Q2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKYSTIAPT ERLPEWLRRP IGDASALERV QGLVKQNRLH TICEEGRCPN    50
    RGECYAAGTA TFLLGGSICT RSCAFCQVEK GQAPMAVDPA EAQRVADAVE 100
    AMQLRYVVLT AVARDDLADH GAALFTTTME AIRARNPLIA IEVLTPDFWG 150
    GCPDPQQAVA AQRERLSTVL AADPVCFNHN LETVQRLQGE VRRGATYERS 200
    LGLLAACREL APTIPTKSGL MLGLGESRDE VIAAMRDLRA VDCQRLTLGQ 250
    YLRPSLAHIP VDRYWTPEEF DELGAVARDL GFAQVRSGPL VRSSYHAAD 299
    Length:299
    Mass (Da):32,691
    Last modified:October 1, 2003 - v1
    Checksum:i89637339E040CC16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07444.1.
    RefSeqiNP_897022.1. NC_005070.1.
    WP_011127794.1. NC_005070.1.

    Genome annotation databases

    EnsemblBacteriaiCAE07444; CAE07444; SYNW0929.
    GeneIDi1730820.
    KEGGisyw:SYNW0929.
    PATRICi23833333. VBISynSp27240_0971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX569691 Genomic DNA. Translation: CAE07444.1 .
    RefSeqi NP_897022.1. NC_005070.1.
    WP_011127794.1. NC_005070.1.

    3D structure databases

    ProteinModelPortali Q7U7Q2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 84588.SYNW0929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE07444 ; CAE07444 ; SYNW0929 .
    GeneIDi 1730820.
    KEGGi syw:SYNW0929.
    PATRICi 23833333. VBISynSp27240_0971.

    Phylogenomic databases

    eggNOGi COG0320.
    HOGENOMi HOG000235997.
    KOi K03644.
    OMAi EWLRRPI.
    OrthoDBi EOG6038ZS.

    Enzyme and pathway databases

    UniPathwayi UPA00538 ; UER00593 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00206. Lipoyl_synth.
    InterProi IPR013785. Aldolase_TIM.
    IPR006638. Elp3/MiaB/NifB.
    IPR003698. Lipoyl_synth.
    IPR007197. rSAM.
    [Graphical view ]
    PANTHERi PTHR10949. PTHR10949. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00510. lipA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WH8102.

    Entry informationi

    Entry nameiLIPA2_SYNPX
    AccessioniPrimary (citable) accession number: Q7U7Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3